Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25203-4 |
| _version_ | 1818998278889406464 |
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| author | Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson |
| author_facet | Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson |
| author_sort | Sunwoo Oh |
| collection | DOAJ |
| description | The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways. |
| first_indexed | 2024-12-20T21:59:00Z |
| format | Article |
| id | doaj.art-f03f488fd0c5499ab43ab73627e76395 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:59:00Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f03f488fd0c5499ab43ab73627e763952022-12-21T19:25:24ZengNature PortfolioNature Communications2041-17232021-08-0112111710.1038/s41467-021-25203-4Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathwaysSunwoo Oh0Elodie Bournique1Danae Bowen2Pégah Jalili3Ambrocio Sanchez4Ian Ward5Alexandra Dananberg6Lavanya Manjunath7Genevieve P. Tran8Bert L. Semler9John Maciejowski10Marcus Seldin11Rémi Buisson12Department of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineMolecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Microbiology and Molecular Genetics, UCI Center for Virus Research, School of Medicine, University of California IrvineDepartment of Microbiology and Molecular Genetics, UCI Center for Virus Research, School of Medicine, University of California IrvineMolecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Biological Chemistry, School of Medicine, University of California IrvineDepartment of Biological Chemistry, School of Medicine, University of California IrvineThe cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.https://doi.org/10.1038/s41467-021-25203-4 |
| spellingShingle | Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways Nature Communications |
| title | Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways |
| title_full | Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways |
| title_fullStr | Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways |
| title_full_unstemmed | Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways |
| title_short | Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways |
| title_sort | genotoxic stress and viral infection induce transient expression of apobec3a and pro inflammatory genes through two distinct pathways |
| url | https://doi.org/10.1038/s41467-021-25203-4 |
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