Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion
Abstract Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer affecting oral cavity. Recent studies have demonstrated that Ubiquitin-specific protease 7 (USP7) was upregulated in several types of cancers. USP7 expression was associated with various proto-oncogenes and tumor suppre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2021-11-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600105&tlng=en |
| _version_ | 1818978930232655872 |
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| author | Xiaojie Yang Jiamin Jin Jinfeng Yang Lihua Zhou Sisi Mi Guangying Qi |
| author_facet | Xiaojie Yang Jiamin Jin Jinfeng Yang Lihua Zhou Sisi Mi Guangying Qi |
| author_sort | Xiaojie Yang |
| collection | DOAJ |
| description | Abstract Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer affecting oral cavity. Recent studies have demonstrated that Ubiquitin-specific protease 7 (USP7) was upregulated in several types of cancers. USP7 expression was associated with various proto-oncogenes and tumor suppressor genes. However, USP7 expression level and its functional role in OSCC is unclear. In the current study, we showed that USP7 expression in OSCC tissues was generally upregulated compared to normal adjacent tissues by using IHC. Furthermore, statistical analysis uncovered that USP7 expression was positively correlated with Ki-67, MMP2, VEGF in OSCC tissues. Importantly, high USP7 expression was significantly correlated with lymph node metastasis and histological differentiation in OSCC patients. So, our hypothesis is that USP7 plays a tumor-promoting role in OSCC. Knocking down of USP7 in tumor cells not only suppressed HSC3 cells proliferation, migration and invasion, but also promoted cell apoptosis. Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway. In conclusion, data presented here suggests that USP7 promotes the progression of OSCC. USP7 may be used as a new therapeutic target for OSCC diagnosis and treatment. |
| first_indexed | 2024-12-20T16:51:27Z |
| format | Article |
| id | doaj.art-f03fa6d776f645e58dd9070d6067e265 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-20T16:51:27Z |
| publishDate | 2021-11-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-f03fa6d776f645e58dd9070d6067e2652022-12-21T19:32:48ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852021-11-0144410.1590/1678-4685-gmb-2021-0058Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasionXiaojie YangJiamin Jinhttps://orcid.org/0000-0001-9141-3350Jinfeng YangLihua ZhouSisi MiGuangying QiAbstract Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer affecting oral cavity. Recent studies have demonstrated that Ubiquitin-specific protease 7 (USP7) was upregulated in several types of cancers. USP7 expression was associated with various proto-oncogenes and tumor suppressor genes. However, USP7 expression level and its functional role in OSCC is unclear. In the current study, we showed that USP7 expression in OSCC tissues was generally upregulated compared to normal adjacent tissues by using IHC. Furthermore, statistical analysis uncovered that USP7 expression was positively correlated with Ki-67, MMP2, VEGF in OSCC tissues. Importantly, high USP7 expression was significantly correlated with lymph node metastasis and histological differentiation in OSCC patients. So, our hypothesis is that USP7 plays a tumor-promoting role in OSCC. Knocking down of USP7 in tumor cells not only suppressed HSC3 cells proliferation, migration and invasion, but also promoted cell apoptosis. Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway. In conclusion, data presented here suggests that USP7 promotes the progression of OSCC. USP7 may be used as a new therapeutic target for OSCC diagnosis and treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600105&tlng=enOral Squamous Cell CarcinomaUSP7siRNAproliferationinvasion |
| spellingShingle | Xiaojie Yang Jiamin Jin Jinfeng Yang Lihua Zhou Sisi Mi Guangying Qi Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion Genetics and Molecular Biology Oral Squamous Cell Carcinoma USP7 siRNA proliferation invasion |
| title | Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| title_full | Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| title_fullStr | Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| title_full_unstemmed | Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| title_short | Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| title_sort | expression of ubiquitin specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion |
| topic | Oral Squamous Cell Carcinoma USP7 siRNA proliferation invasion |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600105&tlng=en |
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