Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head
The weight loss effects of dietary phospholipids have been extensively studied. However, little attention has been paid to the influence of phospholipids (PLs) with different fatty acids and polar headgroups on the development of obesity. High-fat-diet-fed mice were administrated with different kind...
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MDPI AG
2023-10-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/11/555 |
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| author | Lingyu Zhang Jiaqin Mu Jing Meng Wenjin Su Jian Li |
| author_facet | Lingyu Zhang Jiaqin Mu Jing Meng Wenjin Su Jian Li |
| author_sort | Lingyu Zhang |
| collection | DOAJ |
| description | The weight loss effects of dietary phospholipids have been extensively studied. However, little attention has been paid to the influence of phospholipids (PLs) with different fatty acids and polar headgroups on the development of obesity. High-fat-diet-fed mice were administrated with different kinds of PLs (2%, <i>w</i>/<i>w</i>) with specific fatty acids and headgroups, including EPA-enriched phosphatidylcholine/phosphatidylethanolamine/phosphatidylserine (EPA-PC/PE/PS), DHA-PC/PE/PS, Egg-PC/PE/PS, and Soy-PC/PE/PS for eight weeks. Body weight, white adipose tissue weight, and the levels of serum lipid and inflammatory markers were measured. The expression of genes related to lipid metabolism in the liver were determined. The results showed that PLs decreased body weight, fat storage, and circulating lipid levels, and EPA-PLs had the best efficiency. Serum TNF-α, MCP-1 levels were significantly reduced via treatment with DHA-PLs and PS groups. Mechanistic investigation revealed that PLs, especially EPA-PLs and PSs, reduced fat accumulation through enhancing the expression of genes involved in fatty acid β-oxidation (<i>Cpt1a</i>, <i>Cpt2</i>, <i>Cd36</i>, and <i>Acaa1a</i>) and downregulating lipogenesis gene (<i>Srebp1c</i>, <i>Scd1</i>, <i>Fas</i>, and <i>Acc</i>) expression. These data suggest that EPA-PS exhibits the best effects among other PLs in terms of ameliorating obesity, which might be attributed to the fatty acid composition of phospholipids, as well as their headgroup. |
| first_indexed | 2024-03-09T16:40:38Z |
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| last_indexed | 2024-03-09T16:40:38Z |
| publishDate | 2023-10-01 |
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| series | Marine Drugs |
| spelling | doaj.art-f03fc3612bc942acad58c777923353602023-11-24T14:53:06ZengMDPI AGMarine Drugs1660-33972023-10-01211155510.3390/md21110555Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar HeadLingyu Zhang0Jiaqin Mu1Jing Meng2Wenjin Su3Jian Li4College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaThe weight loss effects of dietary phospholipids have been extensively studied. However, little attention has been paid to the influence of phospholipids (PLs) with different fatty acids and polar headgroups on the development of obesity. High-fat-diet-fed mice were administrated with different kinds of PLs (2%, <i>w</i>/<i>w</i>) with specific fatty acids and headgroups, including EPA-enriched phosphatidylcholine/phosphatidylethanolamine/phosphatidylserine (EPA-PC/PE/PS), DHA-PC/PE/PS, Egg-PC/PE/PS, and Soy-PC/PE/PS for eight weeks. Body weight, white adipose tissue weight, and the levels of serum lipid and inflammatory markers were measured. The expression of genes related to lipid metabolism in the liver were determined. The results showed that PLs decreased body weight, fat storage, and circulating lipid levels, and EPA-PLs had the best efficiency. Serum TNF-α, MCP-1 levels were significantly reduced via treatment with DHA-PLs and PS groups. Mechanistic investigation revealed that PLs, especially EPA-PLs and PSs, reduced fat accumulation through enhancing the expression of genes involved in fatty acid β-oxidation (<i>Cpt1a</i>, <i>Cpt2</i>, <i>Cd36</i>, and <i>Acaa1a</i>) and downregulating lipogenesis gene (<i>Srebp1c</i>, <i>Scd1</i>, <i>Fas</i>, and <i>Acc</i>) expression. These data suggest that EPA-PS exhibits the best effects among other PLs in terms of ameliorating obesity, which might be attributed to the fatty acid composition of phospholipids, as well as their headgroup.https://www.mdpi.com/1660-3397/21/11/555phospholipidsobesityfatty acid compositionheadgroupslipid metabolism |
| spellingShingle | Lingyu Zhang Jiaqin Mu Jing Meng Wenjin Su Jian Li Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head Marine Drugs phospholipids obesity fatty acid composition headgroups lipid metabolism |
| title | Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head |
| title_full | Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head |
| title_fullStr | Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head |
| title_full_unstemmed | Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head |
| title_short | Dietary Phospholipids Alleviate Diet-Induced Obesity in Mice: Which Fatty Acids and Which Polar Head |
| title_sort | dietary phospholipids alleviate diet induced obesity in mice which fatty acids and which polar head |
| topic | phospholipids obesity fatty acid composition headgroups lipid metabolism |
| url | https://www.mdpi.com/1660-3397/21/11/555 |
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