Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center
Objective: To evaluate the impact of psoriasis on pregnancy outcomes. Study Design: Data of pregnant women with chronic plaque psoriasis who were followed up at Hacettepe University Hospital between January 1, 2010 and December 31, 2017 were evaluated. Pregnant women with singleton pregnancies w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Network
2019-12-01
|
| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/850 |
| _version_ | 1797920400923951104 |
|---|---|
| author | Efsun Tanacan Atakan Tanacan Erdem Fadiloglu Canan Unal Mehmet Sinan Beksac |
| author_facet | Efsun Tanacan Atakan Tanacan Erdem Fadiloglu Canan Unal Mehmet Sinan Beksac |
| author_sort | Efsun Tanacan |
| collection | DOAJ |
| description | Objective: To evaluate the impact of psoriasis on pregnancy outcomes.
Study Design: Data of pregnant women with chronic plaque psoriasis who were followed up at Hacettepe University Hospital between January 1, 2010 and December 31, 2017 were evaluated. Pregnant women with singleton pregnancies who had chronic plaque psoriasis were included in the study. Patients were divided into two groups based on the clinical course of psoriasis: group 1 (improvement/disease-stable), and group 2 (deterioration). Median maternal age, gravida, parity, gestational week at birth, birthweight, 5th minute APGAR score together with the rates of cesarean section, neonatal intensive care unit admission and pregnancy complications (spontaneous abortion, preterm delivery, fetal growth restriction and preeclampsia) were compared between the groups.
Results: There were 29 (61.7%) patients in group 1 and 18 (38.3%) patients in group 2. Mean values for maternal age, gravida and parity were comparable between the groups (p values were 0.32, 0.09 and 0.17, respectively). Median values for gestational week at birth (39.2 vs 36.1, p =0.002), birthweight (3200 vs 2310, p =0.002) and 5th minute APGAR score (9 vs 7, p <0.001) were statistically significantly lower in group 2. Cesarean section (33.3% vs 71.4%, p =0.02), neonatal intensive care unit admission (11.1% vs 64.3%, p <0.001) and pregnancy complication rates (p =0.003) were statistically significantly higher in group 2. Frequencies of spontaneous abortion, preterm delivery, fetal growth restriction and preeclampsia were 6.9%, 10.3%, 3.4% and 3.4% in group 1, and 22.2%, 27.8%, 16.7% and 16.7% in group 2, respectively.
Conclusion: Deterioration of psoriasis in pregnancy was associated with adverse obstetric outcome. |
| first_indexed | 2024-04-10T14:01:38Z |
| format | Article |
| id | doaj.art-f04125b602d6493489c4c48aef7834ed |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:01:38Z |
| publishDate | 2019-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-f04125b602d6493489c4c48aef7834ed2023-02-15T16:10:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512019-12-0125312813210.21613/GORM.2018.850644Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary CenterEfsun Tanacan0Atakan Tanacan1Erdem Fadiloglu2Canan Unal3Mehmet Sinan BeksacHacettepe UniversityHacettepe UniversityHacettepe UniversityHacettepe UniversityObjective: To evaluate the impact of psoriasis on pregnancy outcomes. Study Design: Data of pregnant women with chronic plaque psoriasis who were followed up at Hacettepe University Hospital between January 1, 2010 and December 31, 2017 were evaluated. Pregnant women with singleton pregnancies who had chronic plaque psoriasis were included in the study. Patients were divided into two groups based on the clinical course of psoriasis: group 1 (improvement/disease-stable), and group 2 (deterioration). Median maternal age, gravida, parity, gestational week at birth, birthweight, 5th minute APGAR score together with the rates of cesarean section, neonatal intensive care unit admission and pregnancy complications (spontaneous abortion, preterm delivery, fetal growth restriction and preeclampsia) were compared between the groups. Results: There were 29 (61.7%) patients in group 1 and 18 (38.3%) patients in group 2. Mean values for maternal age, gravida and parity were comparable between the groups (p values were 0.32, 0.09 and 0.17, respectively). Median values for gestational week at birth (39.2 vs 36.1, p =0.002), birthweight (3200 vs 2310, p =0.002) and 5th minute APGAR score (9 vs 7, p <0.001) were statistically significantly lower in group 2. Cesarean section (33.3% vs 71.4%, p =0.02), neonatal intensive care unit admission (11.1% vs 64.3%, p <0.001) and pregnancy complication rates (p =0.003) were statistically significantly higher in group 2. Frequencies of spontaneous abortion, preterm delivery, fetal growth restriction and preeclampsia were 6.9%, 10.3%, 3.4% and 3.4% in group 1, and 22.2%, 27.8%, 16.7% and 16.7% in group 2, respectively. Conclusion: Deterioration of psoriasis in pregnancy was associated with adverse obstetric outcome.http://gorm.com.tr/index.php/GORM/article/view/850psoriasis, pregnancy, adverse obstetric outcome, autoimmune disease, placental inflammation |
| spellingShingle | Efsun Tanacan Atakan Tanacan Erdem Fadiloglu Canan Unal Mehmet Sinan Beksac Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center Gynecology Obstetrics & Reproductive Medicine psoriasis, pregnancy, adverse obstetric outcome, autoimmune disease, placental inflammation |
| title | Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center |
| title_full | Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center |
| title_fullStr | Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center |
| title_full_unstemmed | Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center |
| title_short | Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center |
| title_sort | psoriasis and pregnancy retrospective evaluation of 47 pregnancies in a tertiary center |
| topic | psoriasis, pregnancy, adverse obstetric outcome, autoimmune disease, placental inflammation |
| url | http://gorm.com.tr/index.php/GORM/article/view/850 |
| work_keys_str_mv | AT efsuntanacan psoriasisandpregnancyretrospectiveevaluationof47pregnanciesinatertiarycenter AT atakantanacan psoriasisandpregnancyretrospectiveevaluationof47pregnanciesinatertiarycenter AT erdemfadiloglu psoriasisandpregnancyretrospectiveevaluationof47pregnanciesinatertiarycenter AT cananunal psoriasisandpregnancyretrospectiveevaluationof47pregnanciesinatertiarycenter AT mehmetsinanbeksac psoriasisandpregnancyretrospectiveevaluationof47pregnanciesinatertiarycenter |