OEA loaded liposomes with the neuroprotective effect for stroke therapy
With high mortality, stroke has become a serious threat to human health. Nevertheless, the strategy for stroke therapy is quite limited in the clinic till now. In this research, we prepared a novel neuroprotective nanoformulation (OEA Liposomes) via encapsulating endogenous N-oleoylethanolamine (OEA...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1014208/full |
| _version_ | 1798036944703193088 |
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| author | Shichao Wu Shichao Wu Shichao Wu Xiangrui Yang Xiangrui Yang Xiangrui Yang |
| author_facet | Shichao Wu Shichao Wu Shichao Wu Xiangrui Yang Xiangrui Yang Xiangrui Yang |
| author_sort | Shichao Wu |
| collection | DOAJ |
| description | With high mortality, stroke has become a serious threat to human health. Nevertheless, the strategy for stroke therapy is quite limited in the clinic till now. In this research, we prepared a novel neuroprotective nanoformulation (OEA Liposomes) via encapsulating endogenous N-oleoylethanolamine (OEA) in liposomes for intravenous administration. The formulation largely increased the solubility and bioavailability of OEA. Then the following systematic experiments stated the excellent neuroprotective effect of OEA Liposomes in vivo. The survival rate of the nanodrug group was largely increased to 75%, while that of the Middle Cerebral Artery Occlusion (MCAO) group was only 41.7%. And the severe neurological functional deficit of the MCAO rats was also significantly improved. What’s more, the OEA Liposomes could inhibit the apoptosis of neurons and the inflammation of reperfusion to a very slight level, indicating their outstanding neuroprotective effect. These results indicated that the OEA Liposomes have a great potential for clinic anti-stroke application. |
| first_indexed | 2024-04-11T21:19:55Z |
| format | Article |
| id | doaj.art-f042e6779d7f409090451978c7c04d84 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T21:19:55Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-f042e6779d7f409090451978c7c04d842022-12-22T04:02:42ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-09-011010.3389/fchem.2022.10142081014208OEA loaded liposomes with the neuroprotective effect for stroke therapyShichao Wu0Shichao Wu1Shichao Wu2Xiangrui Yang3Xiangrui Yang4Xiangrui Yang5Department of Nuclear Medicine, Xiangya Hosptal, Central South University, Changsha, Hunan, ChinaKey Laboratory of Nanobiological Technology of National Health Commission, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Nuclear Medicine, Xiangya Hosptal, Central South University, Changsha, Hunan, ChinaKey Laboratory of Nanobiological Technology of National Health Commission, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaWith high mortality, stroke has become a serious threat to human health. Nevertheless, the strategy for stroke therapy is quite limited in the clinic till now. In this research, we prepared a novel neuroprotective nanoformulation (OEA Liposomes) via encapsulating endogenous N-oleoylethanolamine (OEA) in liposomes for intravenous administration. The formulation largely increased the solubility and bioavailability of OEA. Then the following systematic experiments stated the excellent neuroprotective effect of OEA Liposomes in vivo. The survival rate of the nanodrug group was largely increased to 75%, while that of the Middle Cerebral Artery Occlusion (MCAO) group was only 41.7%. And the severe neurological functional deficit of the MCAO rats was also significantly improved. What’s more, the OEA Liposomes could inhibit the apoptosis of neurons and the inflammation of reperfusion to a very slight level, indicating their outstanding neuroprotective effect. These results indicated that the OEA Liposomes have a great potential for clinic anti-stroke application.https://www.frontiersin.org/articles/10.3389/fchem.2022.1014208/fullOEAstrokeneurprotective effectischemia reperfusiondrug delivery |
| spellingShingle | Shichao Wu Shichao Wu Shichao Wu Xiangrui Yang Xiangrui Yang Xiangrui Yang OEA loaded liposomes with the neuroprotective effect for stroke therapy Frontiers in Chemistry OEA stroke neurprotective effect ischemia reperfusion drug delivery |
| title | OEA loaded liposomes with the neuroprotective effect for stroke therapy |
| title_full | OEA loaded liposomes with the neuroprotective effect for stroke therapy |
| title_fullStr | OEA loaded liposomes with the neuroprotective effect for stroke therapy |
| title_full_unstemmed | OEA loaded liposomes with the neuroprotective effect for stroke therapy |
| title_short | OEA loaded liposomes with the neuroprotective effect for stroke therapy |
| title_sort | oea loaded liposomes with the neuroprotective effect for stroke therapy |
| topic | OEA stroke neurprotective effect ischemia reperfusion drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1014208/full |
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