Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study
Background: Seizures are a common complication of cerebral venous thrombosis. In this study, we intended to define clinical and neuroradiological factors associated with early and late seizures and predictors for seizure recurrence. Methods: The database of our high-volume tertiary stroke center was...
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MDPI AG
2022-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/1/111 |
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| author | Francesca Colò Valerio Brunetti Mariangela Di Muro Elena Rossi Francesca Bartolomei Andrea Maria Alexandre Simone Bellavia Irene Scala Artur Słomka Fabio Pilato Giovanni Frisullo Aldobrando Broccolini Giacomo Della Marca |
| author_facet | Francesca Colò Valerio Brunetti Mariangela Di Muro Elena Rossi Francesca Bartolomei Andrea Maria Alexandre Simone Bellavia Irene Scala Artur Słomka Fabio Pilato Giovanni Frisullo Aldobrando Broccolini Giacomo Della Marca |
| author_sort | Francesca Colò |
| collection | DOAJ |
| description | Background: Seizures are a common complication of cerebral venous thrombosis. In this study, we intended to define clinical and neuroradiological factors associated with early and late seizures and predictors for seizure recurrence. Methods: The database of our high-volume tertiary stroke center was screened for patients diagnosed with cerebral venous thrombosis between April 2006 and July 2021. Demographics, clinical, imaging, and instrumental data were collected. Results: Out of a total of 80 patients, 30 had seizures, either within the first week after onset (22 patients) or after (8 patients). Speech impairment and intracerebral bleeding were statistically associated with seizures in univariate analysis, but in a logistic regression model, only brain damage with hemorrhagic infarct and/or presence of brain hematoma [OR 6.051; 95% CI 1.881–19.468] (<i>p</i> = 0.003) were predicting factors for seizures. Late seizures were significantly more frequent in younger age [OR 0.864; 95% CI 0.763–0.978] (<i>p</i> = 0.020). Early seizures resulted as protective factors for recurrence; an altered state of consciousness at baseline and late seizures resulted as predictive factors for relapses (0.0% vs. 81.0%, <i>p</i> = 0.005, and 100.0% vs. 19.0%, <i>p</i> < 0.005, respectively). Conclusions: Our study confirms brain bleeding as the strongest risk factor for seizures after cerebral venous thrombosis. Recurrence is unusual after early seizures, while the presence of late seizures seems to raise the risk of recurrence. |
| first_indexed | 2024-03-09T11:57:03Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T11:57:03Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f045bedefc8e4c12919fbc223827b3802023-11-30T23:08:11ZengMDPI AGLife2075-17292022-12-0113111110.3390/life13010111Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort StudyFrancesca Colò0Valerio Brunetti1Mariangela Di Muro2Elena Rossi3Francesca Bartolomei4Andrea Maria Alexandre5Simone Bellavia6Irene Scala7Artur Słomka8Fabio Pilato9Giovanni Frisullo10Aldobrando Broccolini11Giacomo Della Marca12School of Medicine, Catholic University, 00168 Rome, ItalyDepartment of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Anesthesiology in Obstetrics, Gynecology, Pain Therapy, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Radiology, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Radiology, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeuroradiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySchool of Medicine, Catholic University, 00168 Rome, ItalySchool of Medicine, Catholic University, 00168 Rome, ItalyDepartment of Pathophysiology, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum, 87-100 Torun, PolandUnit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico, 00128 Rome, ItalyDepartment of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySchool of Medicine, Catholic University, 00168 Rome, ItalySchool of Medicine, Catholic University, 00168 Rome, ItalyBackground: Seizures are a common complication of cerebral venous thrombosis. In this study, we intended to define clinical and neuroradiological factors associated with early and late seizures and predictors for seizure recurrence. Methods: The database of our high-volume tertiary stroke center was screened for patients diagnosed with cerebral venous thrombosis between April 2006 and July 2021. Demographics, clinical, imaging, and instrumental data were collected. Results: Out of a total of 80 patients, 30 had seizures, either within the first week after onset (22 patients) or after (8 patients). Speech impairment and intracerebral bleeding were statistically associated with seizures in univariate analysis, but in a logistic regression model, only brain damage with hemorrhagic infarct and/or presence of brain hematoma [OR 6.051; 95% CI 1.881–19.468] (<i>p</i> = 0.003) were predicting factors for seizures. Late seizures were significantly more frequent in younger age [OR 0.864; 95% CI 0.763–0.978] (<i>p</i> = 0.020). Early seizures resulted as protective factors for recurrence; an altered state of consciousness at baseline and late seizures resulted as predictive factors for relapses (0.0% vs. 81.0%, <i>p</i> = 0.005, and 100.0% vs. 19.0%, <i>p</i> < 0.005, respectively). Conclusions: Our study confirms brain bleeding as the strongest risk factor for seizures after cerebral venous thrombosis. Recurrence is unusual after early seizures, while the presence of late seizures seems to raise the risk of recurrence.https://www.mdpi.com/2075-1729/13/1/111cerebral venous thrombosishemorrhagic infarctseizuresseizures recurrence |
| spellingShingle | Francesca Colò Valerio Brunetti Mariangela Di Muro Elena Rossi Francesca Bartolomei Andrea Maria Alexandre Simone Bellavia Irene Scala Artur Słomka Fabio Pilato Giovanni Frisullo Aldobrando Broccolini Giacomo Della Marca Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study Life cerebral venous thrombosis hemorrhagic infarct seizures seizures recurrence |
| title | Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study |
| title_full | Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study |
| title_fullStr | Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study |
| title_full_unstemmed | Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study |
| title_short | Predicting Factors for Seizures after Cerebral Venous Thrombosis: A Retrospective Single Center Cohort Study |
| title_sort | predicting factors for seizures after cerebral venous thrombosis a retrospective single center cohort study |
| topic | cerebral venous thrombosis hemorrhagic infarct seizures seizures recurrence |
| url | https://www.mdpi.com/2075-1729/13/1/111 |
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