A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report
Bosutinib is a BCR-ABL tyrosine kinase inhibitor approved for the treatment of Philadelphia chromosome–positive chronic myelogenous leukemia. We report a case of bosutinib-induced interstitial granulomatous drug reaction in a 50-year-old Caucasian female with chronic myelogenous leukemia. Histologic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-09-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X18795075 |
| _version_ | 1818081360425779200 |
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| author | Alexander B Aria Leon Chen Auris O Huen |
| author_facet | Alexander B Aria Leon Chen Auris O Huen |
| author_sort | Alexander B Aria |
| collection | DOAJ |
| description | Bosutinib is a BCR-ABL tyrosine kinase inhibitor approved for the treatment of Philadelphia chromosome–positive chronic myelogenous leukemia. We report a case of bosutinib-induced interstitial granulomatous drug reaction in a 50-year-old Caucasian female with chronic myelogenous leukemia. Histologic analysis of a punch biopsy showed diffuse interstitial granulomatous infiltrates consisting of histiocytes amid thickened collagen accompanied by eosinophils. Her lesions improved with clobetasol 0.05% cream. No cases describing BCR-ABL tyrosine kinase inhibitor–associated interstitial granulomatous drug reaction were found in a search of the literature. It is important for physicians to be aware of the risk of interstitial granulomatous drug reaction associated with bosutinib treatment. |
| first_indexed | 2024-12-10T19:04:58Z |
| format | Article |
| id | doaj.art-f045cf5f49d344cea2f936cb9cf6a8af |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-10T19:04:58Z |
| publishDate | 2018-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-f045cf5f49d344cea2f936cb9cf6a8af2022-12-22T01:36:55ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2018-09-01610.1177/2050313X18795075A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case reportAlexander B Aria0Leon Chen1Auris O Huen2Department of Dermatology, The University of Texas Medical School at Houston, Houston, TX, USADepartment of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USABosutinib is a BCR-ABL tyrosine kinase inhibitor approved for the treatment of Philadelphia chromosome–positive chronic myelogenous leukemia. We report a case of bosutinib-induced interstitial granulomatous drug reaction in a 50-year-old Caucasian female with chronic myelogenous leukemia. Histologic analysis of a punch biopsy showed diffuse interstitial granulomatous infiltrates consisting of histiocytes amid thickened collagen accompanied by eosinophils. Her lesions improved with clobetasol 0.05% cream. No cases describing BCR-ABL tyrosine kinase inhibitor–associated interstitial granulomatous drug reaction were found in a search of the literature. It is important for physicians to be aware of the risk of interstitial granulomatous drug reaction associated with bosutinib treatment.https://doi.org/10.1177/2050313X18795075 |
| spellingShingle | Alexander B Aria Leon Chen Auris O Huen A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report SAGE Open Medical Case Reports |
| title | A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report |
| title_full | A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report |
| title_fullStr | A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report |
| title_full_unstemmed | A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report |
| title_short | A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report |
| title_sort | case report of bosutinib induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia a case report |
| url | https://doi.org/10.1177/2050313X18795075 |
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