Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy

Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy

Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR)-modified T cells has revolutionized the field of immune-oncology, showing remarkable efficacy against hematological malignancies. However, its success in solid tumors is limited by factors such as easy recurrence and poor efficacy. Th...

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Bibliographic Details
Main Authors: Wenshuai Li, Xuanxuan Pan, Lirong Chen, Haoshu Cui, Shaocong Mo, Yida Pan, Yuru Shen, Menglin Shi, Jianlin Wu, Feifei Luo, Jie Liu, Na Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
cell metabolism
cancer therapy
optimization strategy
CAR (chimeric antigen receptor) T cells
immunity therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186383/full

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