The Role of Ferrous Ion in the Effect of the Gadolinium-Based Contrast Agents (GBCA) on the Purkinje Cells Arborization: An In Vitro Study

The Role of Ferrous Ion in the Effect of the Gadolinium-Based Contrast Agents (GBCA) on the Purkinje Cells Arborization: An In Vitro Study

Gadolinium deposition in the brain has been observed in areas rich in iron, such as the dentate nucleus of the cerebellum. We investigated the role of Fe<sup>2+</sup> in the effect of gadolinium-based contrast agents (GBCA) on thyroid hormone-mediated Purkinje cell dendritogenesis in a c...

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Bibliographic Details
Main Authors: Achmad Adhipatria Perayabangsa Kartamihardja, Winda Ariyani, Hirofumi Hanaoka, Ayako Taketomi-Takahashi, Noriyuki Koibuchi, Yoshito Tsushima
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Diagnostics
Subjects:
gadolinium (Gd)
gadolinium-based contrast agent (GBCA)
Gd toxicity
transmetallation
Purkinje cells
neuron morphogenesis
Online Access:https://www.mdpi.com/2075-4418/11/12/2310

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