Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study
Both acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairm...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34068-0 |
| _version_ | 1817970488168677376 |
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| author | Manina M. Etter Tomás A. Martins Laila Kulsvehagen Elisabeth Pössnecker Wandrille Duchemin Sabrina Hogan Gretel Sanabria-Diaz Jannis Müller Alessio Chiappini Jonathan Rychen Noëmi Eberhard Raphael Guzman Luigi Mariani Lester Melie-Garcia Emanuela Keller Ilijas Jelcic Hans Pargger Martin Siegemund Jens Kuhle Johanna Oechtering Caroline Eich Alexandar Tzankov Matthias S. Matter Sarp Uzun Özgür Yaldizli Johanna M. Lieb Marios-Nikos Psychogios Karoline Leuzinger Hans H. Hirsch Cristina Granziera Anne-Katrin Pröbstel Gregor Hutter |
| author_facet | Manina M. Etter Tomás A. Martins Laila Kulsvehagen Elisabeth Pössnecker Wandrille Duchemin Sabrina Hogan Gretel Sanabria-Diaz Jannis Müller Alessio Chiappini Jonathan Rychen Noëmi Eberhard Raphael Guzman Luigi Mariani Lester Melie-Garcia Emanuela Keller Ilijas Jelcic Hans Pargger Martin Siegemund Jens Kuhle Johanna Oechtering Caroline Eich Alexandar Tzankov Matthias S. Matter Sarp Uzun Özgür Yaldizli Johanna M. Lieb Marios-Nikos Psychogios Karoline Leuzinger Hans H. Hirsch Cristina Granziera Anne-Katrin Pröbstel Gregor Hutter |
| author_sort | Manina M. Etter |
| collection | DOAJ |
| description | Both acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection. |
| first_indexed | 2024-04-13T20:34:47Z |
| format | Article |
| id | doaj.art-f0470cc90c504832a493429d193b5b41 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T20:34:47Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f0470cc90c504832a493429d193b5b412022-12-22T02:31:04ZengNature PortfolioNature Communications2041-17232022-11-0113112110.1038/s41467-022-34068-0Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional studyManina M. Etter0Tomás A. Martins1Laila Kulsvehagen2Elisabeth Pössnecker3Wandrille Duchemin4Sabrina Hogan5Gretel Sanabria-Diaz6Jannis Müller7Alessio Chiappini8Jonathan Rychen9Noëmi Eberhard10Raphael Guzman11Luigi Mariani12Lester Melie-Garcia13Emanuela Keller14Ilijas Jelcic15Hans Pargger16Martin Siegemund17Jens Kuhle18Johanna Oechtering19Caroline Eich20Alexandar Tzankov21Matthias S. Matter22Sarp Uzun23Özgür Yaldizli24Johanna M. Lieb25Marios-Nikos Psychogios26Karoline Leuzinger27Hans H. Hirsch28Cristina Granziera29Anne-Katrin Pröbstel30Gregor Hutter31Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of BaselBrain Tumor Immunotherapy Lab, Department of Biomedicine, University of BaselDepartments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of BaselDepartments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of BaselsciCORE Center for Scientific Computing, University of BaselBrain Tumor Immunotherapy Lab, Department of Biomedicine, University of BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselDepartment of Neurosurgery, University Hospital BaselDepartment of Neurosurgery, University Hospital BaselDepartment of Neurosurgery, University Hospital BaselDepartment of Neurosurgery, University Hospital BaselDepartment of Neurosurgery, University Hospital BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselNeurosurgical Intensive Care Unit, Department of Neurosurgery and Institute of Intensive Care Medicine, University Hospital ZurichNeuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital ZurichDepartment of Intensive Care Medicine, University Hospital BaselDepartment of Intensive Care Medicine, University Hospital BaselDepartment of Neurology, University Hospital BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselBrain Tumor Immunotherapy Lab, Department of Biomedicine, University of BaselDepartment of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of BaselDepartment of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of BaselDepartment of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselDepartment of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital BaselDepartment of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital BaselDivision of Medical Immunology, Laboratory Medicine, University Hospital BaselClinical Virology, University Hospital BaselTranslational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of BaselDepartments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of BaselBrain Tumor Immunotherapy Lab, Department of Biomedicine, University of BaselBoth acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection.https://doi.org/10.1038/s41467-022-34068-0 |
| spellingShingle | Manina M. Etter Tomás A. Martins Laila Kulsvehagen Elisabeth Pössnecker Wandrille Duchemin Sabrina Hogan Gretel Sanabria-Diaz Jannis Müller Alessio Chiappini Jonathan Rychen Noëmi Eberhard Raphael Guzman Luigi Mariani Lester Melie-Garcia Emanuela Keller Ilijas Jelcic Hans Pargger Martin Siegemund Jens Kuhle Johanna Oechtering Caroline Eich Alexandar Tzankov Matthias S. Matter Sarp Uzun Özgür Yaldizli Johanna M. Lieb Marios-Nikos Psychogios Karoline Leuzinger Hans H. Hirsch Cristina Granziera Anne-Katrin Pröbstel Gregor Hutter Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Nature Communications |
| title | Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study |
| title_full | Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study |
| title_fullStr | Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study |
| title_full_unstemmed | Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study |
| title_short | Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study |
| title_sort | severe neuro covid is associated with peripheral immune signatures autoimmunity and neurodegeneration a prospective cross sectional study |
| url | https://doi.org/10.1038/s41467-022-34068-0 |
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