Targeting Cardiovascular Diseases by Flavonols: An Update
Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1439 |
| _version_ | 1797438151535362048 |
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| author | Aleksandra Kozłowska Dorota Szostak-Węgierek |
| author_facet | Aleksandra Kozłowska Dorota Szostak-Węgierek |
| author_sort | Aleksandra Kozłowska |
| collection | DOAJ |
| description | Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases. |
| first_indexed | 2024-03-09T11:33:06Z |
| format | Article |
| id | doaj.art-f0478705b3f7442fbfb8c414d46400cc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:06Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f0478705b3f7442fbfb8c414d46400cc2023-11-30T23:48:15ZengMDPI AGNutrients2072-66432022-03-01147143910.3390/nu14071439Targeting Cardiovascular Diseases by Flavonols: An UpdateAleksandra Kozłowska0Dorota Szostak-Węgierek1Department of Social Medicine and Public Health, Medical University of Warsaw, Oczki Str. 3, 02-007 Warsaw, PolandDepartment of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, E Ciołka Str. 27, 01-445 Warsaw, PolandFlavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases.https://www.mdpi.com/2072-6643/14/7/1439flavonolsquercetincardiovascular diseasesinflammation |
| spellingShingle | Aleksandra Kozłowska Dorota Szostak-Węgierek Targeting Cardiovascular Diseases by Flavonols: An Update Nutrients flavonols quercetin cardiovascular diseases inflammation |
| title | Targeting Cardiovascular Diseases by Flavonols: An Update |
| title_full | Targeting Cardiovascular Diseases by Flavonols: An Update |
| title_fullStr | Targeting Cardiovascular Diseases by Flavonols: An Update |
| title_full_unstemmed | Targeting Cardiovascular Diseases by Flavonols: An Update |
| title_short | Targeting Cardiovascular Diseases by Flavonols: An Update |
| title_sort | targeting cardiovascular diseases by flavonols an update |
| topic | flavonols quercetin cardiovascular diseases inflammation |
| url | https://www.mdpi.com/2072-6643/14/7/1439 |
| work_keys_str_mv | AT aleksandrakozłowska targetingcardiovasculardiseasesbyflavonolsanupdate AT dorotaszostakwegierek targetingcardiovasculardiseasesbyflavonolsanupdate |