Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Abstract Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing...

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Bibliographic Details
Main Authors: Jintao Bao, Liangjun Zheng, Qi Zhang, Xinya Li, Xuefei Zhang, Zeyang Li, Xue Bai, Zhong Zhang, Wei Huo, Xuyang Zhao, Shujiang Shang, Qingsong Wang, Chen Zhang, Jianguo Ji
Format: Article
Language:English
Published: Oxford University Press 2016-05-01
Series:Protein & Cell
Subjects:
Alzheimer’s disease
microglia
lysosomes
TFEB
SIRT1
deacetylation
Online Access:http://link.springer.com/article/10.1007/s13238-016-0269-2

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