Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study
Abstract Background Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the therapeutic effects of some antipsychotics on sleep variables; however, to our knowledge, the effects of brexpiprazole on sleep architec...
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12317 |
| _version_ | 1797884376636194816 |
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| author | Yusuke Arai Daimei Sasayama Kazuaki Kuraishi Shiho Murata Nobuteru Usuda Mika Tsuchida Yuka Nakajima Shinsuke Washizuka |
| author_facet | Yusuke Arai Daimei Sasayama Kazuaki Kuraishi Shiho Murata Nobuteru Usuda Mika Tsuchida Yuka Nakajima Shinsuke Washizuka |
| author_sort | Yusuke Arai |
| collection | DOAJ |
| description | Abstract Background Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the therapeutic effects of some antipsychotics on sleep variables; however, to our knowledge, the effects of brexpiprazole on sleep architecture have not been examined in patients with schizophrenia. Therefore, we aimed to exploratorily investigate the effect of brexpiprazole on sleep variables measured by polysomnography in patients with schizophrenia. Methods This study included 10 patients with schizophrenia who were originally treated with haloperidol alone. Sleep variables of the participants were measured using polysomnography. After excluding those who did not meet the study criteria, seven patients (five men and two women; mean age [SD], 59.0 [10.0] years) were eligible for further analysis. Polysomnography was repeated at 4 weeks after the participants were prescribed brexpiprazole in addition to haloperidol. We compared the sleep architecture of the participants, measured using polysomnography, before and after taking brexpiprazole. Results Add‐on brexpiprazole significantly prolonged rapid eye movement latency, increased the duration and percentage of stage N2 and stage N3 sleep (min, %), and decreased the duration and percentage of stage rapid eye movement sleep (min, %) at a significance level of nominal p < 0.05. Conclusion Although not significant after correcting for multiple comparisons, the present results showed that add‐on brexpiprazole could alter the sleep architecture of patients with schizophrenia. Future studies are warranted to replicate these findings and to further investigate the beneficial influence of brexpiprazole on sleep. |
| first_indexed | 2024-04-10T04:05:34Z |
| format | Article |
| id | doaj.art-f04a887c31c14e759f749628a220bde3 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-10T04:05:34Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-f04a887c31c14e759f749628a220bde32023-03-13T06:33:30ZengWileyNeuropsychopharmacology Reports2574-173X2023-03-0143111211910.1002/npr2.12317Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary studyYusuke Arai0Daimei Sasayama1Kazuaki Kuraishi2Shiho Murata3Nobuteru Usuda4Mika Tsuchida5Yuka Nakajima6Shinsuke Washizuka7Department of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Shinshu University School of Medicine Matsumoto JapanDepartment of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Kurita Hospital Nagano JapanDepartment of Psychiatry Shinshu University School of Medicine Matsumoto JapanAbstract Background Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the therapeutic effects of some antipsychotics on sleep variables; however, to our knowledge, the effects of brexpiprazole on sleep architecture have not been examined in patients with schizophrenia. Therefore, we aimed to exploratorily investigate the effect of brexpiprazole on sleep variables measured by polysomnography in patients with schizophrenia. Methods This study included 10 patients with schizophrenia who were originally treated with haloperidol alone. Sleep variables of the participants were measured using polysomnography. After excluding those who did not meet the study criteria, seven patients (five men and two women; mean age [SD], 59.0 [10.0] years) were eligible for further analysis. Polysomnography was repeated at 4 weeks after the participants were prescribed brexpiprazole in addition to haloperidol. We compared the sleep architecture of the participants, measured using polysomnography, before and after taking brexpiprazole. Results Add‐on brexpiprazole significantly prolonged rapid eye movement latency, increased the duration and percentage of stage N2 and stage N3 sleep (min, %), and decreased the duration and percentage of stage rapid eye movement sleep (min, %) at a significance level of nominal p < 0.05. Conclusion Although not significant after correcting for multiple comparisons, the present results showed that add‐on brexpiprazole could alter the sleep architecture of patients with schizophrenia. Future studies are warranted to replicate these findings and to further investigate the beneficial influence of brexpiprazole on sleep.https://doi.org/10.1002/npr2.12317atypical antipsychoticbrexpiprazolepolysomnographyschizophreniasleep architecture |
| spellingShingle | Yusuke Arai Daimei Sasayama Kazuaki Kuraishi Shiho Murata Nobuteru Usuda Mika Tsuchida Yuka Nakajima Shinsuke Washizuka Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study Neuropsychopharmacology Reports atypical antipsychotic brexpiprazole polysomnography schizophrenia sleep architecture |
| title | Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study |
| title_full | Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study |
| title_fullStr | Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study |
| title_full_unstemmed | Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study |
| title_short | Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study |
| title_sort | analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia a preliminary study |
| topic | atypical antipsychotic brexpiprazole polysomnography schizophrenia sleep architecture |
| url | https://doi.org/10.1002/npr2.12317 |
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