Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome
Cryptococcal meningoencephalitis (CM) continues to cause major morbidity and mortality in a range of patients such as those immunosuppressed from HIV and with biologic immunosuppressants, including treatments of autoimmunity, malignancies, and conditioning regimens for transplantation. It is current...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.994396/full |
| _version_ | 1811321887668568064 |
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| author | Kenneth Ssebambulidde Seher H. Anjum Jessica C. Hargarten Prashant Chittiboina Shmuel Shoham Seyedmojtaba Seyedmousavi Kieren A. Marr Dima A. Hammoud Bridgette Jeanne Billioux Peter R. Williamson |
| author_facet | Kenneth Ssebambulidde Seher H. Anjum Jessica C. Hargarten Prashant Chittiboina Shmuel Shoham Seyedmojtaba Seyedmousavi Kieren A. Marr Dima A. Hammoud Bridgette Jeanne Billioux Peter R. Williamson |
| author_sort | Kenneth Ssebambulidde |
| collection | DOAJ |
| description | Cryptococcal meningoencephalitis (CM) continues to cause major morbidity and mortality in a range of patients such as those immunosuppressed from HIV and with biologic immunosuppressants, including treatments of autoimmunity, malignancies, and conditioning regimens for transplantation. It is currently the most common cause of non-viral meningitis in the United States. Infections in previously healthy patients also develop with autoantibodies to granulocyte-macrophage colony stimulating factor or with monogenetic defects. In all populations, mortality and significant long-term morbidity occur in 30–50% despite therapy, and immune reconstitution and post-infectious inflammatory response syndromes complicate management. To help with these difficult cases, we present here a practical tutorial of the care of a range of patients with CM in the absence of HIV/AIDS. |
| first_indexed | 2024-04-13T13:25:32Z |
| format | Article |
| id | doaj.art-f04b1a8d291a4b84b413bc272cd381ff |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T13:25:32Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f04b1a8d291a4b84b413bc272cd381ff2022-12-22T02:45:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-12-011310.3389/fneur.2022.994396994396Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndromeKenneth Ssebambulidde0Seher H. Anjum1Jessica C. Hargarten2Prashant Chittiboina3Shmuel Shoham4Seyedmojtaba Seyedmousavi5Kieren A. Marr6Dima A. Hammoud7Bridgette Jeanne Billioux8Peter R. Williamson9Translational Mycology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesTranslational Mycology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesTranslational Mycology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United StatesJohns Hopkins School of Medicine, Baltimore, MD, United StatesMicrobiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United StatesJohns Hopkins School of Medicine, Baltimore, MD, United StatesCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United StatesSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United StatesTranslational Mycology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesCryptococcal meningoencephalitis (CM) continues to cause major morbidity and mortality in a range of patients such as those immunosuppressed from HIV and with biologic immunosuppressants, including treatments of autoimmunity, malignancies, and conditioning regimens for transplantation. It is currently the most common cause of non-viral meningitis in the United States. Infections in previously healthy patients also develop with autoantibodies to granulocyte-macrophage colony stimulating factor or with monogenetic defects. In all populations, mortality and significant long-term morbidity occur in 30–50% despite therapy, and immune reconstitution and post-infectious inflammatory response syndromes complicate management. To help with these difficult cases, we present here a practical tutorial of the care of a range of patients with CM in the absence of HIV/AIDS.https://www.frontiersin.org/articles/10.3389/fneur.2022.994396/fullcryptococcalCryptococcusinfectious diseasesfungusneuroinflammation |
| spellingShingle | Kenneth Ssebambulidde Seher H. Anjum Jessica C. Hargarten Prashant Chittiboina Shmuel Shoham Seyedmojtaba Seyedmousavi Kieren A. Marr Dima A. Hammoud Bridgette Jeanne Billioux Peter R. Williamson Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome Frontiers in Neurology cryptococcal Cryptococcus infectious diseases fungus neuroinflammation |
| title | Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome |
| title_full | Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome |
| title_fullStr | Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome |
| title_full_unstemmed | Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome |
| title_short | Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome |
| title_sort | treatment recommendations for non hiv associated cryptococcal meningoencephalitis including management of post infectious inflammatory response syndrome |
| topic | cryptococcal Cryptococcus infectious diseases fungus neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.994396/full |
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