EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis

EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis

Abstract Background Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through complex mechanisms. Our results provide new insights into the EZH2 epigenetic repression of let-7c that promotes HCC migration induced by HBx. Thus, let-7c and HMG...

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Bibliographic Details
Main Authors: Chen-Shiou Wu, Yi-Chung Chien, Chia‐Jui Yen, Jia-Yan Wu, Li-Yuan Bai, Yung-Luen Yu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cancer Cell International
Subjects:
EZH2
let-7c
miR-99a
Hepatitis B Virus X Antigen
Hepatocellular Carcinoma
Online Access:https://doi.org/10.1186/s12935-023-03002-9

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