| Summary: | <p class="MsoNormal" style="margin-bottom: 0,0000pt; text-align: justify; text-justify: inter-ideograph;" align="justify"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">Earlier we showed that</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> p</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">rofile patients of Truskavets</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">’</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> spa are characterized by a wide range of blood pressure (BP) - from low norm to arterial hypertension</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> III</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> that correspond to the hemodynamics parameters</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">The </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;">purpose</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> of this study is to clarify the autonomic and endocrine accompaniments of quantitative</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">-</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">qualitative BP clusters in the same contingent.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Materials and methods.</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">tonometer “Omron M4-I”, Netherlands)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. The parameters of HRV </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">(</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; color: #222222; font-size: 12,0000pt;">"CardioLab+HRV", Ukraine</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">), plasma levels of Cortisol, Aldosterone, Testosterone, Triiodothyronine and Calcitonin (ELISA)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> as well as Ca-P marker of parathyroid hormone</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">were determined</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">.</span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;"> </span></strong><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Results</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">.</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> In order to identify among the registered parameters, those for which the BP clusters differ from each other, a discriminant analysis was performed.</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">The program </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">forward stepwise </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">included in the discriminant model 29 parameters</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">The most informative among them are HRV-markers of sympathetic tone and sympathetic-vagal balance</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">as well as testosterone and cortisol, </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">whose levels are maximal in patients with hypertension II, while minimal in patients with low norm BP, on the one hand, and markers of vagal tone and Kerd</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">oe</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> vegetative index, the levels of which are polar, on the other hand.</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">The accuracy of patient classification is 98,9%</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. </span><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Conclusion</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">Autonomic and endocrine accompaniments</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;"> of </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">quantitative-qualitative blood pressure clusters corresponding to the existing ideas about the regulation of blood pressure</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; font-size: 12,0000pt;">.</span></p>
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