Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
Abstract Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresent...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23238-1 |
| _version_ | 1811230472635678720 |
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| author | Sangwan Park M. Isabel Casanova Danika L. Bannasch Nicole L. Daley Soohyun Kim John Kuchtey Filipe Espinheira Gomes Brian C. Leonard Kathryn L. Good Bianca da C. Martins Christopher J. Murphy Sara M. Thomasy |
| author_facet | Sangwan Park M. Isabel Casanova Danika L. Bannasch Nicole L. Daley Soohyun Kim John Kuchtey Filipe Espinheira Gomes Brian C. Leonard Kathryn L. Good Bianca da C. Martins Christopher J. Murphy Sara M. Thomasy |
| author_sort | Sangwan Park |
| collection | DOAJ |
| description | Abstract Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case–control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans. |
| first_indexed | 2024-04-12T10:29:53Z |
| format | Article |
| id | doaj.art-f050ae50c7b7467fbed621402c5b9467 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T10:29:53Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f050ae50c7b7467fbed621402c5b94672022-12-22T03:36:52ZengNature PortfolioScientific Reports2045-23222022-11-011211810.1038/s41598-022-23238-1Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibilitySangwan Park0M. Isabel Casanova1Danika L. Bannasch2Nicole L. Daley3Soohyun Kim4John Kuchtey5Filipe Espinheira Gomes6Brian C. Leonard7Kathryn L. Good8Bianca da C. Martins9Christopher J. Murphy10Sara M. Thomasy11Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Population Health and Reproduction, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisVanderbilt Eye Institute, Vanderbilt University Medical CenterDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University IthacaDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-DavisAbstract Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case–control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans.https://doi.org/10.1038/s41598-022-23238-1 |
| spellingShingle | Sangwan Park M. Isabel Casanova Danika L. Bannasch Nicole L. Daley Soohyun Kim John Kuchtey Filipe Espinheira Gomes Brian C. Leonard Kathryn L. Good Bianca da C. Martins Christopher J. Murphy Sara M. Thomasy Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility Scientific Reports |
| title | Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility |
| title_full | Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility |
| title_fullStr | Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility |
| title_full_unstemmed | Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility |
| title_short | Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility |
| title_sort | ocular morphologic traits in the american cocker spaniel may confer primary angle closure glaucoma susceptibility |
| url | https://doi.org/10.1038/s41598-022-23238-1 |
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