Correlation of the metabolic syndrome with IL-27 in schizophrenia patients
Introduction: Growing evidence suggests that antipsychotic drugs affect the level of cytokines and metabolic syndrome parameters in schizophrenic patients. The present study aimed to investigate the serum markers of metabolic syndrome, including low-density lipoprotein (LDL), high-density lipoprotei...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-03-01
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| Series: | Journal of Fasting and Health |
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| Online Access: | http://jnfh.mums.ac.ir/article_12318_547e9db2f47221e230e97de964fff5a0.pdf |
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| author | Salar Andarzi Salah Hajinejad Hamidreza Miri |
| author_facet | Salar Andarzi Salah Hajinejad Hamidreza Miri |
| author_sort | Salar Andarzi |
| collection | DOAJ |
| description | Introduction: Growing evidence suggests that antipsychotic drugs affect the level of cytokines and metabolic syndrome parameters in schizophrenic patients. The present study aimed to investigate the serum markers of metabolic syndrome, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), fasting blood sugar (FBS),total cholesterol, and insulin, and interleukin-27 (IL-27) in the patients with schizophrenia and compared the levels with healthy subjects. Methods: In this cross-sectional study, the serum level of IL-27 was measured in 45 patients with schizophrenia and 45 healthy subjects using the ELISA. In addition, the markers of metabolic syndrome were measured in Dr. Salehi Laboratory in Yasouj, Iran. Data analysis was performed in SPSS version 21. Results: A significant increase was observed in IL-27 in the patients with schizophrenia (P= 0.043) compared to the healthy controls. Evaluation of the risk factors of metabolic syndrome in schizophrenic patients compared to the controls indicated no significant differences in the body mass index (P=0.764), systolic blood pressure (P=0.670), diastolic blood pressure (P=0.216), total cholesterol (P=0.103), TG (P=0.097), and LDL (P=0.255). However, the serum levels of HDL (P=0.012) and insulin (P=0.001) significantly decreased and increased, respectively in schizophrenic patients compared to the controls. Moreover, a strong, positive correlation was observed between the levels of insulin and LDL andIL-27, with the correlation-coefficients of 0.312 and 0.641, respectively. A negative correlation was also denoted between IL-27 and HDL with the correlation-coefficient of -0.413 (P=0.005). The associations between IL-27 and the other markers of metabolic syndrome were not considered significant. Conclusion: According to the results, changes in IL-27 may affect the Pathophysiology of schizophrenia. Antipsychotic therapy has been reported to increase the serum levels of IL-27, which in turn exacerbate and increase the incidence of metabolic disorders. |
| first_indexed | 2024-12-20T09:08:51Z |
| format | Article |
| id | doaj.art-f051548ba31b43b2b1d8b8b2e685b539 |
| institution | Directory Open Access Journal |
| issn | 2345-2587 2345-2587 |
| language | English |
| last_indexed | 2024-12-20T09:08:51Z |
| publishDate | 2019-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Fasting and Health |
| spelling | doaj.art-f051548ba31b43b2b1d8b8b2e685b5392022-12-21T19:45:38ZengMashhad University of Medical SciencesJournal of Fasting and Health2345-25872345-25872019-03-017111010.22038/jnfh.2019.36674.115912318Correlation of the metabolic syndrome with IL-27 in schizophrenia patientsSalar Andarzi0Salah Hajinejad1Hamidreza Miri2Department of genetics, Faculty of Sciences, University of Shahid Chamran Ahvaz, Ahvaz, IranDepartment of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, IranDepartment of Laboratory Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran | Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranIntroduction: Growing evidence suggests that antipsychotic drugs affect the level of cytokines and metabolic syndrome parameters in schizophrenic patients. The present study aimed to investigate the serum markers of metabolic syndrome, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), fasting blood sugar (FBS),total cholesterol, and insulin, and interleukin-27 (IL-27) in the patients with schizophrenia and compared the levels with healthy subjects. Methods: In this cross-sectional study, the serum level of IL-27 was measured in 45 patients with schizophrenia and 45 healthy subjects using the ELISA. In addition, the markers of metabolic syndrome were measured in Dr. Salehi Laboratory in Yasouj, Iran. Data analysis was performed in SPSS version 21. Results: A significant increase was observed in IL-27 in the patients with schizophrenia (P= 0.043) compared to the healthy controls. Evaluation of the risk factors of metabolic syndrome in schizophrenic patients compared to the controls indicated no significant differences in the body mass index (P=0.764), systolic blood pressure (P=0.670), diastolic blood pressure (P=0.216), total cholesterol (P=0.103), TG (P=0.097), and LDL (P=0.255). However, the serum levels of HDL (P=0.012) and insulin (P=0.001) significantly decreased and increased, respectively in schizophrenic patients compared to the controls. Moreover, a strong, positive correlation was observed between the levels of insulin and LDL andIL-27, with the correlation-coefficients of 0.312 and 0.641, respectively. A negative correlation was also denoted between IL-27 and HDL with the correlation-coefficient of -0.413 (P=0.005). The associations between IL-27 and the other markers of metabolic syndrome were not considered significant. Conclusion: According to the results, changes in IL-27 may affect the Pathophysiology of schizophrenia. Antipsychotic therapy has been reported to increase the serum levels of IL-27, which in turn exacerbate and increase the incidence of metabolic disorders.http://jnfh.mums.ac.ir/article_12318_547e9db2f47221e230e97de964fff5a0.pdfSchizophreniaIL-27Anti psychotic drugsmetabolic syndrome |
| spellingShingle | Salar Andarzi Salah Hajinejad Hamidreza Miri Correlation of the metabolic syndrome with IL-27 in schizophrenia patients Journal of Fasting and Health Schizophrenia IL-27 Anti psychotic drugs metabolic syndrome |
| title | Correlation of the metabolic syndrome with IL-27 in schizophrenia patients |
| title_full | Correlation of the metabolic syndrome with IL-27 in schizophrenia patients |
| title_fullStr | Correlation of the metabolic syndrome with IL-27 in schizophrenia patients |
| title_full_unstemmed | Correlation of the metabolic syndrome with IL-27 in schizophrenia patients |
| title_short | Correlation of the metabolic syndrome with IL-27 in schizophrenia patients |
| title_sort | correlation of the metabolic syndrome with il 27 in schizophrenia patients |
| topic | Schizophrenia IL-27 Anti psychotic drugs metabolic syndrome |
| url | http://jnfh.mums.ac.ir/article_12318_547e9db2f47221e230e97de964fff5a0.pdf |
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