Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes
Background: Cluster analyses were previously performed to identify asthma phenotypes underlying asthma syndrome. Although a large number of patients with asthma develop the disease later in life, these previous cluster analyses focused mainly patients with younger-onset asthma. Methods: Cluster anal...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015301155 |
| _version_ | 1811310137956106240 |
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| author | Yoshiko Kaneko Hironori Masuko Tohru Sakamoto Hiroaki Iijima Takashi Naito Yohei Yatagai Hideyasu Yamada Satoshi Konno Masaharu Nishimura Emiko Noguchi Nobuyuki Hizawa |
| author_facet | Yoshiko Kaneko Hironori Masuko Tohru Sakamoto Hiroaki Iijima Takashi Naito Yohei Yatagai Hideyasu Yamada Satoshi Konno Masaharu Nishimura Emiko Noguchi Nobuyuki Hizawa |
| author_sort | Yoshiko Kaneko |
| collection | DOAJ |
| description | Background: Cluster analyses were previously performed to identify asthma phenotypes underlying asthma syndrome. Although a large number of patients with asthma develop the disease later in life, these previous cluster analyses focused mainly patients with younger-onset asthma.
Methods: Cluster analysis examined the existence of distinct phenotypes of late-onset asthma in Japanese patients with adult asthma. We then associated genotypes at the CCL5, TSLP, IL4, and ADRB2 genes with the clusters of asthma identified.
Results: Using the 8 variables of age, sex, age at onset of the disease, smoking status, total serum IgE, %FEV1, FEV1/FVC, and specific IgE responsiveness to common inhaled allergens, two-step cluster analysis of 880 Japanese adult asthma patients identified 6 phenotypes: cluster A (n = 155): older age at onset, no airflow obstruction; cluster B (n = 170): childhood onset, normal-to-mild airflow obstruction; cluster C (n = 119): childhood onset, the longest disease duration, and moderate-to-severe airflow obstruction; cluster D (n = 108): older age at onset, severe airflow obstruction; cluster E (n = 130): middle-age at onset, no airflow obstruction; and cluster F (n = 198): older age at onset, mild-to-moderate airflow obstruction. The CCL5-28C>G genotype was significantly associated with clusters A, B and D (OR 1.65, p = 0.0021; 1.67, 0.018; and 1.74, 0.011, respectively). The ADRB2 Arg16Gly genotype was also associated with clusters B and D (OR 0.47, p = 0.0004; and 0.63, 0.034, respectively).
Conclusions: The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes. Genetic and phenotypic data have the potential to elucidate the pheno- typic heterogeneity and pathophysiology of asthma. |
| first_indexed | 2024-04-13T09:54:13Z |
| format | Article |
| id | doaj.art-f0519bdf033f4ee99b71f145c5cceccc |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-13T09:54:13Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
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| series | Allergology International |
| spelling | doaj.art-f0519bdf033f4ee99b71f145c5cceccc2022-12-22T02:51:30ZengElsevierAllergology International1323-89302013-01-0162111312110.2332/allergolint.12-OA-0467Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 GenotypesYoshiko Kaneko0Hironori Masuko1Tohru Sakamoto2Hiroaki Iijima3Takashi Naito4Yohei Yatagai5Hideyasu Yamada6Satoshi Konno7Masaharu Nishimura8Emiko Noguchi9Nobuyuki Hizawa10Department of Pulmonary MedicineDepartment of Pulmonary MedicineDepartment of Pulmonary MedicineTsukuba Medical Center, IbarakiTsukuba Medical Center, IbarakiDepartment of Pulmonary MedicineDepartment of Pulmonary MedicineFirst Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.First Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan.Department of Medical Genetics, Faculty of Medicine, University of TsukubaDepartment of Pulmonary MedicineBackground: Cluster analyses were previously performed to identify asthma phenotypes underlying asthma syndrome. Although a large number of patients with asthma develop the disease later in life, these previous cluster analyses focused mainly patients with younger-onset asthma. Methods: Cluster analysis examined the existence of distinct phenotypes of late-onset asthma in Japanese patients with adult asthma. We then associated genotypes at the CCL5, TSLP, IL4, and ADRB2 genes with the clusters of asthma identified. Results: Using the 8 variables of age, sex, age at onset of the disease, smoking status, total serum IgE, %FEV1, FEV1/FVC, and specific IgE responsiveness to common inhaled allergens, two-step cluster analysis of 880 Japanese adult asthma patients identified 6 phenotypes: cluster A (n = 155): older age at onset, no airflow obstruction; cluster B (n = 170): childhood onset, normal-to-mild airflow obstruction; cluster C (n = 119): childhood onset, the longest disease duration, and moderate-to-severe airflow obstruction; cluster D (n = 108): older age at onset, severe airflow obstruction; cluster E (n = 130): middle-age at onset, no airflow obstruction; and cluster F (n = 198): older age at onset, mild-to-moderate airflow obstruction. The CCL5-28C>G genotype was significantly associated with clusters A, B and D (OR 1.65, p = 0.0021; 1.67, 0.018; and 1.74, 0.011, respectively). The ADRB2 Arg16Gly genotype was also associated with clusters B and D (OR 0.47, p = 0.0004; and 0.63, 0.034, respectively). Conclusions: The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes. Genetic and phenotypic data have the potential to elucidate the pheno- typic heterogeneity and pathophysiology of asthma.http://www.sciencedirect.com/science/article/pii/S1323893015301155ADRB2age at onsetasthma phenotypeCCL5lung function |
| spellingShingle | Yoshiko Kaneko Hironori Masuko Tohru Sakamoto Hiroaki Iijima Takashi Naito Yohei Yatagai Hideyasu Yamada Satoshi Konno Masaharu Nishimura Emiko Noguchi Nobuyuki Hizawa Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes Allergology International ADRB2 age at onset asthma phenotype CCL5 lung function |
| title | Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes |
| title_full | Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes |
| title_fullStr | Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes |
| title_full_unstemmed | Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes |
| title_short | Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes |
| title_sort | asthma phenotypes in japanese adults their associations with the ccl5 adrb2 genotypes |
| topic | ADRB2 age at onset asthma phenotype CCL5 lung function |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015301155 |
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