Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review)
The aim of review is to discuss the results of studies on diagnosis of tissue hypoxia by laser-induced spectroscopy, as well as to identify promising trends and prospects of this technique for its further application in experimental and clinical medicine.The review presents the findings of studies o...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-12-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1832 |
| _version_ | 1797874170186432512 |
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| author | Anastasiya S. Babkina |
| author_facet | Anastasiya S. Babkina |
| author_sort | Anastasiya S. Babkina |
| collection | DOAJ |
| description | The aim of review is to discuss the results of studies on diagnosis of tissue hypoxia by laser-induced spectroscopy, as well as to identify promising trends and prospects of this technique for its further application in experimental and clinical medicine.The review presents the findings of studies of the fluorescence intensity of endogenous fluorophore molecules (reduced nicotinamide adenine dinucleotide, oxidized flavin adenine dinucleotide) as markers of ischemic injury of internal organs (brain, heart, liver, kidneys, etc.). The principles of fluorescence laser-induced spectroscopy in vivo are discussed. The historical aspects of the subject are also covered. The results of the use of the technique in experimental and clinical studies of tissue hypoxia and ischemia are shown. Difficulties in interpreting the intensity values of autofluorescent signal of the studied molecules are revealed. It was noted that the tissue autofluorescence in a long-term anoxia remains unknown, and there are no structured ideas about the impact of exogenous and endogenous factors on autofluorescence intensity.In conclusion, the use of laser-induced fluorescence spectroscopy to diagnose tissue ischemia is a promising area of experimental and clinical medicine, which still has various unresolved issues, despite a large number of studies in this domain. |
| first_indexed | 2024-04-10T01:27:46Z |
| format | Article |
| id | doaj.art-f052f138987047cabc152e9215f8eb2b |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:27:46Z |
| publishDate | 2019-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-f052f138987047cabc152e9215f8eb2b2023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-12-01156506110.15360/1813-9779-2019-6-50-611717Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review)Anastasiya S. Babkina0НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР; Российский университет дружбы народовThe aim of review is to discuss the results of studies on diagnosis of tissue hypoxia by laser-induced spectroscopy, as well as to identify promising trends and prospects of this technique for its further application in experimental and clinical medicine.The review presents the findings of studies of the fluorescence intensity of endogenous fluorophore molecules (reduced nicotinamide adenine dinucleotide, oxidized flavin adenine dinucleotide) as markers of ischemic injury of internal organs (brain, heart, liver, kidneys, etc.). The principles of fluorescence laser-induced spectroscopy in vivo are discussed. The historical aspects of the subject are also covered. The results of the use of the technique in experimental and clinical studies of tissue hypoxia and ischemia are shown. Difficulties in interpreting the intensity values of autofluorescent signal of the studied molecules are revealed. It was noted that the tissue autofluorescence in a long-term anoxia remains unknown, and there are no structured ideas about the impact of exogenous and endogenous factors on autofluorescence intensity.In conclusion, the use of laser-induced fluorescence spectroscopy to diagnose tissue ischemia is a promising area of experimental and clinical medicine, which still has various unresolved issues, despite a large number of studies in this domain.https://www.reanimatology.com/rmt/article/view/1832лазер-индуцированная флуоресценциянаднфадгипоксияэндогенные флуорофорытканевая гипоксияишемия головного мозга |
| spellingShingle | Anastasiya S. Babkina Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) Общая реаниматология лазер-индуцированная флуоресценция надн фад гипоксия эндогенные флуорофоры тканевая гипоксия ишемия головного мозга |
| title | Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) |
| title_full | Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) |
| title_fullStr | Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) |
| title_full_unstemmed | Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) |
| title_short | Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review) |
| title_sort | laser induced fluorescence spectroscopy in the diagnosis of tissue hypoxia review |
| topic | лазер-индуцированная флуоресценция надн фад гипоксия эндогенные флуорофоры тканевая гипоксия ишемия головного мозга |
| url | https://www.reanimatology.com/rmt/article/view/1832 |
| work_keys_str_mv | AT anastasiyasbabkina laserinducedfluorescencespectroscopyinthediagnosisoftissuehypoxiareview |