The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technolo...

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Main Authors: Frédéric Lange, Luca Giannoni, Ilias Tachtsidis
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/11/10/4616
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author Frédéric Lange
Luca Giannoni
Ilias Tachtsidis
author_facet Frédéric Lange
Luca Giannoni
Ilias Tachtsidis
author_sort Frédéric Lange
collection DOAJ
description Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technological limitations, mainly from the light sources and/or detection electronics. In the past 20 years, the developments of supercontinuum laser (SCL) enabled to unlock some of these limitations, enabling the development of system and methodologies relevant for medical use, notably in terms of spectral monitoring. In this review, we focus on the use of SCL in biomedical diffuse optics, from instrumentation and methods developments to their use for medical applications. A total of 95 publications were identified, from 1993 to 2021. We discuss the advantages of the SCL to cover a large spectral bandwidth with a high spectral power and fast switching against the disadvantages of cost, bulkiness, and long warm up times. Finally, we summarize the utility of using such light sources in the development and application of diffuse optics in biomedical sciences and clinical applications.
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spelling doaj.art-f0554821a4d14781a2ed0d2f2460ae752023-11-21T20:17:26ZengMDPI AGApplied Sciences2076-34172021-05-011110461610.3390/app11104616The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral ImagingFrédéric Lange0Luca Giannoni1Ilias Tachtsidis2Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKBiomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKBiomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKOptical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technological limitations, mainly from the light sources and/or detection electronics. In the past 20 years, the developments of supercontinuum laser (SCL) enabled to unlock some of these limitations, enabling the development of system and methodologies relevant for medical use, notably in terms of spectral monitoring. In this review, we focus on the use of SCL in biomedical diffuse optics, from instrumentation and methods developments to their use for medical applications. A total of 95 publications were identified, from 1993 to 2021. We discuss the advantages of the SCL to cover a large spectral bandwidth with a high spectral power and fast switching against the disadvantages of cost, bulkiness, and long warm up times. Finally, we summarize the utility of using such light sources in the development and application of diffuse optics in biomedical sciences and clinical applications.https://www.mdpi.com/2076-3417/11/10/4616supercontinuum laserNIRStissue opticsdiffuse optics
spellingShingle Frédéric Lange
Luca Giannoni
Ilias Tachtsidis
The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
Applied Sciences
supercontinuum laser
NIRS
tissue optics
diffuse optics
title The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
title_full The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
title_fullStr The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
title_full_unstemmed The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
title_short The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
title_sort use of supercontinuum laser sources in biomedical diffuse optics unlocking the power of multispectral imaging
topic supercontinuum laser
NIRS
tissue optics
diffuse optics
url https://www.mdpi.com/2076-3417/11/10/4616
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