Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts
We tested the capacity of leaf (Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, and Satureja viminea) and root (Uncaria tomentosa) extracts to inhibit edema induced by Bothrops asper snake venom. Edema-forming activity was studied plethysmographically in the rat hind paw model...
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| Format: | Article |
| Language: | English |
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Universidad de Costa Rica
2006-06-01
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| Series: | Revista de Biología Tropical |
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| Online Access: | http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442006000200001 |
| _version_ | 1827162574603419648 |
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| author | Beatriz Badilla Fernando Chaves Gerardo Mora Luis J Poveda |
| author_facet | Beatriz Badilla Fernando Chaves Gerardo Mora Luis J Poveda |
| author_sort | Beatriz Badilla |
| collection | DOAJ |
| description | We tested the capacity of leaf (Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, and Satureja viminea) and root (Uncaria tomentosa) extracts to inhibit edema induced by Bothrops asper snake venom. Edema-forming activity was studied plethysmographically in the rat hind paw model. Groups of rats were injected intraperitoneally with various doses of each extract and, one hour later, venom was injected subcutaneously in the right hind paw. Edema was assessed at various time intervals. The edematogenic activity was inhibited in those animals that received an injection U. tomentosa, C. nutans or L. speciosa extract. The extract of U. baccifera showed a slight inhibition of the venom effect. Extract from S. viminea and, to a lesser extent that of U. leptuphylla, induced a pro-inflammatory effect, increasing the edema at doses of 250 mg/kg at one and two hours. Rev. Biol. Trop. 54(2): 245-252. Epub 2006 Jun 01.<br>Se investigó la capacidad de los extractos de las hojas de Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, Satureja viminea y de la raíz de Uncaria tomentosa para inhibir el edema inducido por el veneno de Bothrops asper por métodos pletismométricos. Los grupos de ratas fueron inyectados intraperitonealmente con varias dosis de cada extracto y una hora mas tarde se inyectó veneno por vía subcutánea en la pata trasera derecha de la rata. Se evaluó el edema en distintos intervalos de tiempo. Los resultados muestran que la actividad edematogénica fue inhibida en los animales que recibieron los extractos de raíz de U. tomentosa, hojas de C. nutans y L. speciosa. Los extractos de hojas de U. baccifera mostraron leve inhibición del efecto del veneno. El extracto de hojas de S. viminea y en menor grado el de U. leptuphylla indujeron un efecto pro inflamatorio. |
| first_indexed | 2024-03-12T09:46:41Z |
| format | Article |
| id | doaj.art-f055b64457254556b92a6fef55dcc2df |
| institution | Directory Open Access Journal |
| issn | 0034-7744 2215-2075 |
| language | English |
| last_indexed | 2025-03-21T00:46:59Z |
| publishDate | 2006-06-01 |
| publisher | Universidad de Costa Rica |
| record_format | Article |
| series | Revista de Biología Tropical |
| spelling | doaj.art-f055b64457254556b92a6fef55dcc2df2024-08-03T05:53:52ZengUniversidad de Costa RicaRevista de Biología Tropical0034-77442215-20752006-06-01542245252Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extractsBeatriz BadillaFernando ChavesGerardo MoraLuis J PovedaWe tested the capacity of leaf (Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, and Satureja viminea) and root (Uncaria tomentosa) extracts to inhibit edema induced by Bothrops asper snake venom. Edema-forming activity was studied plethysmographically in the rat hind paw model. Groups of rats were injected intraperitoneally with various doses of each extract and, one hour later, venom was injected subcutaneously in the right hind paw. Edema was assessed at various time intervals. The edematogenic activity was inhibited in those animals that received an injection U. tomentosa, C. nutans or L. speciosa extract. The extract of U. baccifera showed a slight inhibition of the venom effect. Extract from S. viminea and, to a lesser extent that of U. leptuphylla, induced a pro-inflammatory effect, increasing the edema at doses of 250 mg/kg at one and two hours. Rev. Biol. Trop. 54(2): 245-252. Epub 2006 Jun 01.<br>Se investigó la capacidad de los extractos de las hojas de Urera baccifera, Loasa speciosa, Urtica leptuphylla, Chaptalia nutans, Satureja viminea y de la raíz de Uncaria tomentosa para inhibir el edema inducido por el veneno de Bothrops asper por métodos pletismométricos. Los grupos de ratas fueron inyectados intraperitonealmente con varias dosis de cada extracto y una hora mas tarde se inyectó veneno por vía subcutánea en la pata trasera derecha de la rata. Se evaluó el edema en distintos intervalos de tiempo. Los resultados muestran que la actividad edematogénica fue inhibida en los animales que recibieron los extractos de raíz de U. tomentosa, hojas de C. nutans y L. speciosa. Los extractos de hojas de U. baccifera mostraron leve inhibición del efecto del veneno. El extracto de hojas de S. viminea y en menor grado el de U. leptuphylla indujeron un efecto pro inflamatorio.http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442006000200001actividad anti-edematogénicaextractos de plantasvenenosserpientesBothrops asperanti-edematogenic activityplant extractssnake venomBothrops asper |
| spellingShingle | Beatriz Badilla Fernando Chaves Gerardo Mora Luis J Poveda Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts Revista de Biología Tropical actividad anti-edematogénica extractos de plantas venenos serpientes Bothrops asper anti-edematogenic activity plant extracts snake venom Bothrops asper |
| title | Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts |
| title_full | Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts |
| title_fullStr | Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts |
| title_full_unstemmed | Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts |
| title_short | Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts |
| title_sort | edema induced by bothrops asper squamata viperidae snake venom and its inhibition by costa rican plant extracts |
| topic | actividad anti-edematogénica extractos de plantas venenos serpientes Bothrops asper anti-edematogenic activity plant extracts snake venom Bothrops asper |
| url | http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442006000200001 |
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