PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition

PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition

Abstract Background Resistance to temozolomide (TMZ) is a major obstacle to preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play a variety of roles in GBM, the lncRNAs that regulate TMZ resistance have not yet been clearly elucidated. This study aims to...

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Bibliographic Details
Main Authors: Zijie Gao, Jianye Xu, Yang Fan, Yanhua Qi, Shaobo Wang, Shulin Zhao, Xing Guo, Hao Xue, Lin Deng, Rongrong Zhao, Chong Sun, Ping Zhang, Gang Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PDIA3P1
Temozolomide
Proneural-to-mesenchymal transition
Glioma stem cells
C/EBPβ
MDM2
Online Access:https://doi.org/10.1186/s13046-022-02431-0

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