Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis
Mycobacterium tuberculosis (M. tuberculosis) resides mainly inside macrophages, which produce nitric oxide (NO) to combat microbial infections. Earlier studies revealed that proteasome-associated genes are required for M. tuberculosis to resist NO via a previously uncharacterized mech...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2015-05-01
|
| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/cytokinins-beyond-plants-synthesis-by-mycobacterium-tuberculosis/ |
| _version_ | 1819294690534490112 |
|---|---|
| author | Marie I. Samanovic K. Heran Darwin |
| author_facet | Marie I. Samanovic K. Heran Darwin |
| author_sort | Marie I. Samanovic |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (M. tuberculosis) resides mainly inside macrophages, which produce nitric oxide (NO) to combat microbial infections. Earlier studies revealed that proteasome-associated genes are required for M. tuberculosis to resist NO via a previously uncharacterized mechanism. Twelve years later, we elucidated the link between proteasome function and NO resistance in M. tuberculosis in Molecular Cell, 57 (2015), pp. 984–994. In a proteasome degradation-defective mutant, Rv1205, a homologue of the plant enzyme LONELY GUY (LOG) that is involved in the synthesis of phytohormones called cytokinins, accumulates and as a consequence results in the overproduction of cytokinins. Cytokinins break down into aldehydes that kill mycobacteria in the presence of NO. Importantly, this new discovery reveals for the first time that a mammalian bacterial pathogen produces cytokinins and leaves us with the question: why is M. tuberculosis, an exclusively human pathogen, producing cytokinins? |
| first_indexed | 2024-12-24T04:30:20Z |
| format | Article |
| id | doaj.art-f058dadcf9994e409aa04d2c83406e24 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-24T04:30:20Z |
| publishDate | 2015-05-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-f058dadcf9994e409aa04d2c83406e242022-12-21T17:15:28ZengShared Science Publishers OGMicrobial Cell2311-26382015-05-012516817010.15698/mic2015.05.203123455678Cytokinins beyond plants: synthesis by Mycobacterium tuberculosisMarie I. Samanovic0K. Heran Darwin1New York University School of Medicine, Department of Microbiology, New York, NY 10016 USA.New York University School of Medicine, Department of Microbiology, New York, NY 10016 USA.Mycobacterium tuberculosis (M. tuberculosis) resides mainly inside macrophages, which produce nitric oxide (NO) to combat microbial infections. Earlier studies revealed that proteasome-associated genes are required for M. tuberculosis to resist NO via a previously uncharacterized mechanism. Twelve years later, we elucidated the link between proteasome function and NO resistance in M. tuberculosis in Molecular Cell, 57 (2015), pp. 984–994. In a proteasome degradation-defective mutant, Rv1205, a homologue of the plant enzyme LONELY GUY (LOG) that is involved in the synthesis of phytohormones called cytokinins, accumulates and as a consequence results in the overproduction of cytokinins. Cytokinins break down into aldehydes that kill mycobacteria in the presence of NO. Importantly, this new discovery reveals for the first time that a mammalian bacterial pathogen produces cytokinins and leaves us with the question: why is M. tuberculosis, an exclusively human pathogen, producing cytokinins?http://microbialcell.com/researcharticles/cytokinins-beyond-plants-synthesis-by-mycobacterium-tuberculosis/Mycobacterium tuberculosisproteasomenitric oxideLONELY GUYcytokinins |
| spellingShingle | Marie I. Samanovic K. Heran Darwin Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis Microbial Cell Mycobacterium tuberculosis proteasome nitric oxide LONELY GUY cytokinins |
| title | Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis |
| title_full | Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis |
| title_fullStr | Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis |
| title_full_unstemmed | Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis |
| title_short | Cytokinins beyond plants: synthesis by Mycobacterium tuberculosis |
| title_sort | cytokinins beyond plants synthesis by mycobacterium tuberculosis |
| topic | Mycobacterium tuberculosis proteasome nitric oxide LONELY GUY cytokinins |
| url | http://microbialcell.com/researcharticles/cytokinins-beyond-plants-synthesis-by-mycobacterium-tuberculosis/ |
| work_keys_str_mv | AT marieisamanovic cytokininsbeyondplantssynthesisbymycobacteriumtuberculosis AT kherandarwin cytokininsbeyondplantssynthesisbymycobacteriumtuberculosis |