Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny
The genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracell...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178736/full |
| _version_ | 1827942672774463488 |
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| author | Laurence Don Wai Luu Vasilli Kasimov Vasilli Kasimov Samuel Phillips Garry S. A. Myers Martina Jelocnik |
| author_facet | Laurence Don Wai Luu Vasilli Kasimov Vasilli Kasimov Samuel Phillips Garry S. A. Myers Martina Jelocnik |
| author_sort | Laurence Don Wai Luu |
| collection | DOAJ |
| description | The genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracellular host environments has been transformed due to the expansion of chlamydial genomes. This review explores the current state of knowledge in Chlamydia genomics and how whole genome sequencing has revolutionised our understanding of Chlamydia virulence, evolution, and phylogeny over the past two and a half decades. This review will also highlight developments in multi-omics and other approaches that have complemented whole genome sequencing to advance knowledge of Chlamydia pathogenesis and future directions for chlamydial genomics. |
| first_indexed | 2024-03-13T10:01:44Z |
| format | Article |
| id | doaj.art-f059caf824c145758f06c5d00868c338 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-13T10:01:44Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f059caf824c145758f06c5d00868c3382023-05-23T05:08:59ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-05-011310.3389/fcimb.2023.11787361178736Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogenyLaurence Don Wai Luu0Vasilli Kasimov1Vasilli Kasimov2Samuel Phillips3Garry S. A. Myers4Martina Jelocnik5School of Life Sciences, University of Technology Sydney, Sydney, NSW, AustraliaCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD, AustraliaSchool of Science, Technology and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, AustraliaCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD, AustraliaAustralian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, AustraliaCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD, AustraliaThe genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracellular host environments has been transformed due to the expansion of chlamydial genomes. This review explores the current state of knowledge in Chlamydia genomics and how whole genome sequencing has revolutionised our understanding of Chlamydia virulence, evolution, and phylogeny over the past two and a half decades. This review will also highlight developments in multi-omics and other approaches that have complemented whole genome sequencing to advance knowledge of Chlamydia pathogenesis and future directions for chlamydial genomics.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178736/fullChlamydiaceaeChlamydia trachomatisgenomicsgenome contentwhole genome sequencenext generation sequencing |
| spellingShingle | Laurence Don Wai Luu Vasilli Kasimov Vasilli Kasimov Samuel Phillips Garry S. A. Myers Martina Jelocnik Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny Frontiers in Cellular and Infection Microbiology Chlamydiaceae Chlamydia trachomatis genomics genome content whole genome sequence next generation sequencing |
| title | Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny |
| title_full | Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny |
| title_fullStr | Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny |
| title_full_unstemmed | Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny |
| title_short | Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny |
| title_sort | genome organization and genomics in chlamydia whole genome sequencing increases understanding of chlamydial virulence evolution and phylogeny |
| topic | Chlamydiaceae Chlamydia trachomatis genomics genome content whole genome sequence next generation sequencing |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178736/full |
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