Temporary amygdala inhibition reduces stress effects in female mice
The current study investigated the effect of temporary inhibition of amygdala in response to metabolic changes caused by stress in female mice. Unilateral and bilateral amygdala cannulation was carried out, and after a week of recovery, 2% lidocaine hydrochloride was injected into the mice amygdalae...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123216300479 |
| _version_ | 1818216791674978304 |
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| author | Jila Rezaeian Dalooei Hedayat Sahraei Gholam Hossein Meftahi Maryam Khosravi Zahra Bahari Boshra Hatef Alireza Mohammadi Fateme Nicaeili Fateme Eftekhari Fateme Ghamari Mohamadmehdi Hadipour Gholamreza Kaka |
| author_facet | Jila Rezaeian Dalooei Hedayat Sahraei Gholam Hossein Meftahi Maryam Khosravi Zahra Bahari Boshra Hatef Alireza Mohammadi Fateme Nicaeili Fateme Eftekhari Fateme Ghamari Mohamadmehdi Hadipour Gholamreza Kaka |
| author_sort | Jila Rezaeian Dalooei |
| collection | DOAJ |
| description | The current study investigated the effect of temporary inhibition of amygdala in response to metabolic changes caused by stress in female mice. Unilateral and bilateral amygdala cannulation was carried out, and after a week of recovery, 2% lidocaine hydrochloride was injected into the mice amygdalae five minutes before the induction of stress. A communication box was employed to induce stress for four consecutive days and plasma corticosterone, food and water intake, weight changes, and anorexia were measured as stress-induced metabolic changes. Results demonstrated that stress, increases stress, increased plasma corticosterone concentrations, weight, food, and water intake. Temporary inhibition of the amygdala slightly decreased plasma corticosterone concentrations, but did not fully reduce the effect of stress. The bilateral injection of lidocaine hydrochloride to the amygdala reduced the effect of stress and reduced water intake and weight. Unilateral injection of lidocaine hydrochloride into the left and right amygdala reduced food intake. In conclusion, the present study demonstrated that the left side and right side of amygdala nuclei play a different role in metabolic responses in stress. |
| first_indexed | 2024-12-12T06:57:35Z |
| format | Article |
| id | doaj.art-f05b0ae98a8d4cc59ef35e627cbfec46 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 2090-1224 |
| language | English |
| last_indexed | 2024-12-12T06:57:35Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-f05b0ae98a8d4cc59ef35e627cbfec462022-12-22T00:33:55ZengElsevierJournal of Advanced Research2090-12322090-12242016-09-017564364910.1016/j.jare.2016.06.008Temporary amygdala inhibition reduces stress effects in female miceJila Rezaeian Dalooei0Hedayat Sahraei1Gholam Hossein Meftahi2Maryam Khosravi3Zahra Bahari4Boshra Hatef5Alireza Mohammadi6Fateme Nicaeili7Fateme Eftekhari8Fateme Ghamari9Mohamadmehdi Hadipour10Gholamreza Kaka11Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Biology, Islamic Azad University, North Tehran Branch, Tehran, IranDepartment of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Biology, Islamic Azad University, North Tehran Branch, Tehran, IranDepartment of Biology, Islamic Azad University, North Tehran Branch, Tehran, IranDepartment of Biology, Islamic Azad University, North Tehran Branch, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranNeuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranThe current study investigated the effect of temporary inhibition of amygdala in response to metabolic changes caused by stress in female mice. Unilateral and bilateral amygdala cannulation was carried out, and after a week of recovery, 2% lidocaine hydrochloride was injected into the mice amygdalae five minutes before the induction of stress. A communication box was employed to induce stress for four consecutive days and plasma corticosterone, food and water intake, weight changes, and anorexia were measured as stress-induced metabolic changes. Results demonstrated that stress, increases stress, increased plasma corticosterone concentrations, weight, food, and water intake. Temporary inhibition of the amygdala slightly decreased plasma corticosterone concentrations, but did not fully reduce the effect of stress. The bilateral injection of lidocaine hydrochloride to the amygdala reduced the effect of stress and reduced water intake and weight. Unilateral injection of lidocaine hydrochloride into the left and right amygdala reduced food intake. In conclusion, the present study demonstrated that the left side and right side of amygdala nuclei play a different role in metabolic responses in stress.http://www.sciencedirect.com/science/article/pii/S2090123216300479AnorexiaCommunication boxCorticosteroneFood intakeHypothalamic–pituitary–adrenal axisLidocaine hydrochloride |
| spellingShingle | Jila Rezaeian Dalooei Hedayat Sahraei Gholam Hossein Meftahi Maryam Khosravi Zahra Bahari Boshra Hatef Alireza Mohammadi Fateme Nicaeili Fateme Eftekhari Fateme Ghamari Mohamadmehdi Hadipour Gholamreza Kaka Temporary amygdala inhibition reduces stress effects in female mice Journal of Advanced Research Anorexia Communication box Corticosterone Food intake Hypothalamic–pituitary–adrenal axis Lidocaine hydrochloride |
| title | Temporary amygdala inhibition reduces stress effects in female mice |
| title_full | Temporary amygdala inhibition reduces stress effects in female mice |
| title_fullStr | Temporary amygdala inhibition reduces stress effects in female mice |
| title_full_unstemmed | Temporary amygdala inhibition reduces stress effects in female mice |
| title_short | Temporary amygdala inhibition reduces stress effects in female mice |
| title_sort | temporary amygdala inhibition reduces stress effects in female mice |
| topic | Anorexia Communication box Corticosterone Food intake Hypothalamic–pituitary–adrenal axis Lidocaine hydrochloride |
| url | http://www.sciencedirect.com/science/article/pii/S2090123216300479 |
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