Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation
Abstract A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive dynamics theory is that as populations adapt, their newly enhanced capacities to exploit resources alter fitne...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45008-5 |
| _version_ | 1797274134361669632 |
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| author | Michael B. Doud Animesh Gupta Victor Li Sarah J. Medina Caesar A. De La Fuente Justin R. Meyer |
| author_facet | Michael B. Doud Animesh Gupta Victor Li Sarah J. Medina Caesar A. De La Fuente Justin R. Meyer |
| author_sort | Michael B. Doud |
| collection | DOAJ |
| description | Abstract A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive dynamics theory is that as populations adapt, their newly enhanced capacities to exploit resources alter fitness payoffs and restructure the landscape in ways that promote speciation by opening new adaptive pathways. While there have been indirect tests of this theory, to our knowledge none have measured how fitness landscapes deform during adaptation, or test whether these shifts promote diversification. Here, we achieve this by studying bacteriophage $$\lambda$$ λ , a virus that readily speciates into co-existing receptor specialists under controlled laboratory conditions. We use a high-throughput gene editing-phenotyping technology to measure $$\lambda$$ λ ’s fitness landscape in the presence of different evolved- $$\lambda$$ λ competitors and find that the fitness effects of individual mutations, and their epistatic interactions, depend on the competitor. Using these empirical data, we simulate $$\lambda$$ λ ’s evolution on an unchanging landscape and one that recapitulates how the landscape deforms during evolution. $$\lambda$$ λ heterogeneity only evolves in the shifting landscape regime. This study provides a test of adaptive dynamics, and, more broadly, shows how fitness landscapes dynamically change during adaptation, potentiating phenomena like speciation by opening new adaptive pathways. |
| first_indexed | 2024-03-07T14:55:01Z |
| format | Article |
| id | doaj.art-f05ce5ec0d4d47bea8fccdb8e6850b5b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:55:01Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f05ce5ec0d4d47bea8fccdb8e6850b5b2024-03-05T19:31:50ZengNature PortfolioNature Communications2041-17232024-01-0115111210.1038/s41467-024-45008-5Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciationMichael B. Doud0Animesh Gupta1Victor Li2Sarah J. Medina3Caesar A. De La Fuente4Justin R. Meyer5Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San DiegoDepartment of Ecology, Behavior and Evolution, University of California San DiegoDepartment of Ecology, Behavior and Evolution, University of California San DiegoDepartment of Ecology, Behavior and Evolution, University of California San DiegoDepartment of Ecology, Behavior and Evolution, University of California San DiegoDepartment of Ecology, Behavior and Evolution, University of California San DiegoAbstract A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive dynamics theory is that as populations adapt, their newly enhanced capacities to exploit resources alter fitness payoffs and restructure the landscape in ways that promote speciation by opening new adaptive pathways. While there have been indirect tests of this theory, to our knowledge none have measured how fitness landscapes deform during adaptation, or test whether these shifts promote diversification. Here, we achieve this by studying bacteriophage $$\lambda$$ λ , a virus that readily speciates into co-existing receptor specialists under controlled laboratory conditions. We use a high-throughput gene editing-phenotyping technology to measure $$\lambda$$ λ ’s fitness landscape in the presence of different evolved- $$\lambda$$ λ competitors and find that the fitness effects of individual mutations, and their epistatic interactions, depend on the competitor. Using these empirical data, we simulate $$\lambda$$ λ ’s evolution on an unchanging landscape and one that recapitulates how the landscape deforms during evolution. $$\lambda$$ λ heterogeneity only evolves in the shifting landscape regime. This study provides a test of adaptive dynamics, and, more broadly, shows how fitness landscapes dynamically change during adaptation, potentiating phenomena like speciation by opening new adaptive pathways.https://doi.org/10.1038/s41467-024-45008-5 |
| spellingShingle | Michael B. Doud Animesh Gupta Victor Li Sarah J. Medina Caesar A. De La Fuente Justin R. Meyer Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation Nature Communications |
| title | Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation |
| title_full | Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation |
| title_fullStr | Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation |
| title_full_unstemmed | Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation |
| title_short | Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation |
| title_sort | competition driven eco evolutionary feedback reshapes bacteriophage lambda s fitness landscape and enables speciation |
| url | https://doi.org/10.1038/s41467-024-45008-5 |
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