Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis
Abstract Background Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear. Methods We...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3970-5 |
| _version_ | 1828768963951067136 |
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| author | Eileen Shaw Megan S. Farris Chelsea R. Stone Jeroen W. G. Derksen Rhys Johnson Robert J. Hilsden Christine M. Friedenreich Darren R. Brenner |
| author_facet | Eileen Shaw Megan S. Farris Chelsea R. Stone Jeroen W. G. Derksen Rhys Johnson Robert J. Hilsden Christine M. Friedenreich Darren R. Brenner |
| author_sort | Eileen Shaw |
| collection | DOAJ |
| description | Abstract Background Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear. Methods We searched MEDLINE for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017. Fifteen and three studies were eligible for inclusion for body mass index and first-degree family history of colorectal cancer subgroups, respectively. Estimates of the highest to lowest comparison of physical activity for each subgroup of risk were pooled using random-effects models. Results The pooled associations of physical activity and colorectal cancer risk for those without and with a first-degree family history of colorectal cancer were 0.56 (95% confidence interval (CI) = 0.39–0.80) and 0.72 (95% CI = 0.39–1.32), respectively (pheterogeneity = 0.586). The pooled associations of physical activity and colorectal cancer risk for the low and high body mass index groups were 0.74 (95% CI = 0.66–0.83) and 0.65 (95% CI = 0.53–0.79), respectively (pheterogeneity = 0.389). Conclusions Overall, a stronger relative risk of physical activity on colorectal cancer risk was observed in the higher body mass index group, although the difference was not statistically significant, suggesting an added benefit of physical activity as a cancer prevention strategy in population groups with strong risk factors for colorectal cancer. Additional research among these subgroups is warranted. |
| first_indexed | 2024-12-11T13:39:20Z |
| format | Article |
| id | doaj.art-f05f06b308b3440c8a8820d0b01640f4 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T13:39:20Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f05f06b308b3440c8a8820d0b01640f42022-12-22T01:04:52ZengBMCBMC Cancer1471-24072018-01-0118111510.1186/s12885-017-3970-5Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysisEileen Shaw0Megan S. Farris1Chelsea R. Stone2Jeroen W. G. Derksen3Rhys Johnson4Robert J. Hilsden5Christine M. Friedenreich6Darren R. Brenner7Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Community Health Sciences, Cumming School of Medicine, University of CalgaryDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health ServicesAbstract Background Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear. Methods We searched MEDLINE for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017. Fifteen and three studies were eligible for inclusion for body mass index and first-degree family history of colorectal cancer subgroups, respectively. Estimates of the highest to lowest comparison of physical activity for each subgroup of risk were pooled using random-effects models. Results The pooled associations of physical activity and colorectal cancer risk for those without and with a first-degree family history of colorectal cancer were 0.56 (95% confidence interval (CI) = 0.39–0.80) and 0.72 (95% CI = 0.39–1.32), respectively (pheterogeneity = 0.586). The pooled associations of physical activity and colorectal cancer risk for the low and high body mass index groups were 0.74 (95% CI = 0.66–0.83) and 0.65 (95% CI = 0.53–0.79), respectively (pheterogeneity = 0.389). Conclusions Overall, a stronger relative risk of physical activity on colorectal cancer risk was observed in the higher body mass index group, although the difference was not statistically significant, suggesting an added benefit of physical activity as a cancer prevention strategy in population groups with strong risk factors for colorectal cancer. Additional research among these subgroups is warranted.http://link.springer.com/article/10.1186/s12885-017-3970-5ExerciseColorectal neoplasmsBody mass indexFamily historyRisk |
| spellingShingle | Eileen Shaw Megan S. Farris Chelsea R. Stone Jeroen W. G. Derksen Rhys Johnson Robert J. Hilsden Christine M. Friedenreich Darren R. Brenner Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis BMC Cancer Exercise Colorectal neoplasms Body mass index Family history Risk |
| title | Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis |
| title_full | Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis |
| title_fullStr | Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis |
| title_full_unstemmed | Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis |
| title_short | Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis |
| title_sort | effects of physical activity on colorectal cancer risk among family history and body mass index subgroups a systematic review and meta analysis |
| topic | Exercise Colorectal neoplasms Body mass index Family history Risk |
| url | http://link.springer.com/article/10.1186/s12885-017-3970-5 |
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