Novel Benzo[<i>f</i>]coumarin Derivatives as Probable Acetylcholinesterase Inhibitors: Synthesis, In Vitro, and In Silico Studies for Evaluation of Their Anti-AChE Activity

Novel Benzo[<i>f</i>]coumarin Derivatives as Probable Acetylcholinesterase Inhibitors: Synthesis, In Vitro, and In Silico Studies for Evaluation of Their Anti-AChE Activity

Novel benzo[f]coumarin derivatives bearing pyrimidine unit were successfully synthesized. The target is to develop novel acetylcholinesterase inhibitors. The benzo[f]coumarin chalcone 4 was prepared via Claisen-Schmidt condensation between 3-acetyl-5,6-benzocoumarin and 4-hydroxybenzaldehyde in the...

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Bibliographic Details
Main Authors: Zaizafoon Nabeel, Qassim Abdul-Hussein Jaber, Nabeel Abed Abdul-Rida
Format: Article
Language:English
Published: Department of Chemistry, Universitas Gadjah Mada 2021-10-01
Series:Indonesian Journal of Chemistry
Subjects:
benzo[f]coumarin
pyrimidine
chalcone
acetylcholinesterase
Online Access:https://jurnal.ugm.ac.id/ijc/article/view/65663

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