RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity
The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity tha...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/10/2007 |
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| author | Vlatka Ivanišević Lidia Žilić Marina Čunko Hana Fadiga Ivana Munitić Igor Jurak |
| author_facet | Vlatka Ivanišević Lidia Žilić Marina Čunko Hana Fadiga Ivana Munitić Igor Jurak |
| author_sort | Vlatka Ivanišević |
| collection | DOAJ |
| description | The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses. |
| first_indexed | 2024-03-10T20:50:22Z |
| format | Article |
| id | doaj.art-f06151de4c52411cb061822e57af1adc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T20:50:22Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f06151de4c52411cb061822e57af1adc2023-11-19T18:26:49ZengMDPI AGViruses1999-49152023-09-011510200710.3390/v15102007RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of ComplexityVlatka Ivanišević0Lidia Žilić1Marina Čunko2Hana Fadiga3Ivana Munitić4Igor Jurak5Department of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, CroatiaThe Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses.https://www.mdpi.com/1999-4915/15/10/2007herpesvirusADARdsRNARNA editingmiRNAlatency |
| spellingShingle | Vlatka Ivanišević Lidia Žilić Marina Čunko Hana Fadiga Ivana Munitić Igor Jurak RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity Viruses herpesvirus ADAR dsRNA RNA editing miRNA latency |
| title | RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| title_full | RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| title_fullStr | RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| title_full_unstemmed | RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| title_short | RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| title_sort | rna editing dependent and independent roles of adenosine deaminases acting on rna proteins in herpesvirus infection hints on another layer of complexity |
| topic | herpesvirus ADAR dsRNA RNA editing miRNA latency |
| url | https://www.mdpi.com/1999-4915/15/10/2007 |
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