Apoptin causes apoptosis in HepG‐2 cells via Ca2+ imbalance and activation of the mitochondrial apoptotic pathway

Apoptin causes apoptosis in HepG‐2 cells via Ca2+ imbalance and activation of the mitochondrial apoptotic pathway

Abstract Background Apoptin is derived from the chicken anemia virus and exhibits specific cytotoxic effects against tumor cells. Herein, we found that Apoptin induced a strong and lasting endoplasmic reticulum (ER) stress response, Ca2+ imbalance, and triggered the mitochondrial apoptotic pathway. ...

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Bibliographic Details
Main Authors: Xiaoyang Yu, Tongxing Wang, Yue Li, Yiquan Li, Bing Bai, Jinbo Fang, Jicheng Han, Shanzhi Li, Zhiru Xiu, Zirui Liu, Xia Yang, Yaru Li, Guangze Zhu, Ningyi Jin, Chao Shang, Xiao Li, Yilong Zhu
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Cancer Medicine
Subjects:
apoptin
Ca2+ imbalance
endoplasmic reticulum stress
mitochondria apoptosis pathway
mitochondria structural injury
Online Access:https://doi.org/10.1002/cam4.5528

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