Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia
Background: Preeclampsia is a condition associated with systemic disorders in the mother and the fetus. However, the exact causes of preeclampsia are unknown, but several genetics and environmental factors play role in development of this disease. Major histocompatibility complex role is very import...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Sciences
2017-09-01
|
| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-251&slc_lang=en&sid=1 |
| _version_ | 1818864464880992256 |
|---|---|
| author | Mahmoud Mohammadi Touraj Farazmandfar Majid Shahbazi |
| author_facet | Mahmoud Mohammadi Touraj Farazmandfar Majid Shahbazi |
| author_sort | Mahmoud Mohammadi |
| collection | DOAJ |
| description | Background: Preeclampsia is a condition associated with systemic disorders in the mother and the fetus. However, the exact causes of preeclampsia are unknown, but several genetics and environmental factors play role in development of this disease. Major histocompatibility complex role is very important during pregnancy through which the fetus is not rejected by mother’s immune system. Objective: In this study, we investigated the relationship of the human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism with preeclampsia. Materials and Methods: Genomic DNA of 181 pregnant women with a history of preeclampsia as the case group and 228 pregnant women with no history of preeclampsia as the controls were extracted. The HLA-DQA1*0102/HLA-DQB1*0602 polymorphisms of all DNA samples were identified by the SSP-PCR method. Frequencies difference of variables between case and control groups were calculated by Chi-square test. The ethnic origin of the participants in this study was extracted from their medical records. Results: There was a significant association between preeclampsia and Sistani ethnic group (p=0.031). Moreover, there was a significant association between preeclampsia and frequencies of allele HLA-DQB1*0602 (p<0.001), and genotypes of heterozygote (+0102/-0602) (p<0.001) and negative homozygote (-0102/-0602) (p=0.005). There also was an association between allele HLA-DQB1*0602 and preeclampsia in Fars ethnic group (p=0.028). Conclusion: It seems that immune incompatibility may have an important role in preeclampsia predisposition. According to our results, the lack of locus HLA-DQB1*0602 may be a risk factor for preeclampsia. |
| first_indexed | 2024-12-19T10:32:05Z |
| format | Article |
| id | doaj.art-f062a1c41caa4a24a2fbb235d5eb9c2c |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-12-19T10:32:05Z |
| publishDate | 2017-09-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-f062a1c41caa4a24a2fbb235d5eb9c2c2022-12-21T20:25:44ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722017-09-01159569574Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsiaMahmoud Mohammadi0Touraj Farazmandfar1Majid Shahbazi2 Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Background: Preeclampsia is a condition associated with systemic disorders in the mother and the fetus. However, the exact causes of preeclampsia are unknown, but several genetics and environmental factors play role in development of this disease. Major histocompatibility complex role is very important during pregnancy through which the fetus is not rejected by mother’s immune system. Objective: In this study, we investigated the relationship of the human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism with preeclampsia. Materials and Methods: Genomic DNA of 181 pregnant women with a history of preeclampsia as the case group and 228 pregnant women with no history of preeclampsia as the controls were extracted. The HLA-DQA1*0102/HLA-DQB1*0602 polymorphisms of all DNA samples were identified by the SSP-PCR method. Frequencies difference of variables between case and control groups were calculated by Chi-square test. The ethnic origin of the participants in this study was extracted from their medical records. Results: There was a significant association between preeclampsia and Sistani ethnic group (p=0.031). Moreover, there was a significant association between preeclampsia and frequencies of allele HLA-DQB1*0602 (p<0.001), and genotypes of heterozygote (+0102/-0602) (p<0.001) and negative homozygote (-0102/-0602) (p=0.005). There also was an association between allele HLA-DQB1*0602 and preeclampsia in Fars ethnic group (p=0.028). Conclusion: It seems that immune incompatibility may have an important role in preeclampsia predisposition. According to our results, the lack of locus HLA-DQB1*0602 may be a risk factor for preeclampsia.http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-251&slc_lang=en&sid=1Preeclampsia HLA-DQ Genotyping. |
| spellingShingle | Mahmoud Mohammadi Touraj Farazmandfar Majid Shahbazi Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia International Journal of Reproductive BioMedicine Preeclampsia HLA-DQ Genotyping. |
| title | Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia |
| title_full | Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia |
| title_fullStr | Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia |
| title_full_unstemmed | Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia |
| title_short | Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia |
| title_sort | relationship between human leukocyte antigen hla dqa1 0102 hla dqb1 0602 polymorphism and preeclampsia |
| topic | Preeclampsia HLA-DQ Genotyping. |
| url | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-251&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mahmoudmohammadi relationshipbetweenhumanleukocyteantigenhladqa10102hladqb10602polymorphismandpreeclampsia AT tourajfarazmandfar relationshipbetweenhumanleukocyteantigenhladqa10102hladqb10602polymorphismandpreeclampsia AT majidshahbazi relationshipbetweenhumanleukocyteantigenhladqa10102hladqb10602polymorphismandpreeclampsia |