Adiponectin and insulin: molecular mechanisms of metabolic disorders
Adiponectin, the most common plasma adipocytokine, plays a crucial metabolic and anti-inflammatory role. With insulin resistance associated with obesity, an increase of adiponectin concentration, which leads to the activation of signaling pathways involved in the regulation of metabolism, occurs. Cu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2020-10-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3003 |
| _version_ | 1797872864171393024 |
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| author | E. G. Uchasova O. V. Gruzdeva E. V. Belik Yu. A. Dyleva |
| author_facet | E. G. Uchasova O. V. Gruzdeva E. V. Belik Yu. A. Dyleva |
| author_sort | E. G. Uchasova |
| collection | DOAJ |
| description | Adiponectin, the most common plasma adipocytokine, plays a crucial metabolic and anti-inflammatory role. With insulin resistance associated with obesity, an increase of adiponectin concentration, which leads to the activation of signaling pathways involved in the regulation of metabolism, occurs. Currently, adiponectin is being investigated as a potential therapeutic target for metabolic syndrome, although more research is required to understand the underlying mechanisms controlling its levels. In this review, we will examine the main mechanisms that control adiponectin levels in blood serum and its role in insulin-sensitizing effect, as well as evaluate the potential use of adiponectin and its receptors as a potential therapeutic target. |
| first_indexed | 2024-04-10T01:05:51Z |
| format | Article |
| id | doaj.art-f0654d829b3c428186c42cbba1912fbd |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:51Z |
| publishDate | 2020-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-f0654d829b3c428186c42cbba1912fbd2023-03-13T09:58:26ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-10-0119318819710.20538/1682-0363-2020-3-188-1971662Adiponectin and insulin: molecular mechanisms of metabolic disordersE. G. Uchasova0O. V. Gruzdeva1E. V. Belik2Yu. A. Dyleva3Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)Adiponectin, the most common plasma adipocytokine, plays a crucial metabolic and anti-inflammatory role. With insulin resistance associated with obesity, an increase of adiponectin concentration, which leads to the activation of signaling pathways involved in the regulation of metabolism, occurs. Currently, adiponectin is being investigated as a potential therapeutic target for metabolic syndrome, although more research is required to understand the underlying mechanisms controlling its levels. In this review, we will examine the main mechanisms that control adiponectin levels in blood serum and its role in insulin-sensitizing effect, as well as evaluate the potential use of adiponectin and its receptors as a potential therapeutic target.https://bulletin.ssmu.ru/jour/article/view/3003адипонектининсулинадипоцитыожирение |
| spellingShingle | E. G. Uchasova O. V. Gruzdeva E. V. Belik Yu. A. Dyleva Adiponectin and insulin: molecular mechanisms of metabolic disorders Бюллетень сибирской медицины адипонектин инсулин адипоциты ожирение |
| title | Adiponectin and insulin: molecular mechanisms of metabolic disorders |
| title_full | Adiponectin and insulin: molecular mechanisms of metabolic disorders |
| title_fullStr | Adiponectin and insulin: molecular mechanisms of metabolic disorders |
| title_full_unstemmed | Adiponectin and insulin: molecular mechanisms of metabolic disorders |
| title_short | Adiponectin and insulin: molecular mechanisms of metabolic disorders |
| title_sort | adiponectin and insulin molecular mechanisms of metabolic disorders |
| topic | адипонектин инсулин адипоциты ожирение |
| url | https://bulletin.ssmu.ru/jour/article/view/3003 |
| work_keys_str_mv | AT eguchasova adiponectinandinsulinmolecularmechanismsofmetabolicdisorders AT ovgruzdeva adiponectinandinsulinmolecularmechanismsofmetabolicdisorders AT evbelik adiponectinandinsulinmolecularmechanismsofmetabolicdisorders AT yuadyleva adiponectinandinsulinmolecularmechanismsofmetabolicdisorders |