Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?
Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of...
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| Format: | Article |
| Language: | English |
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Selçuk University
2023-08-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2781423 |
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| author | Kader Zeybek Aydoğan İsmail Baloğlu Fethi Yönet Yasin Öztürk Hakan Ozer |
| author_facet | Kader Zeybek Aydoğan İsmail Baloğlu Fethi Yönet Yasin Öztürk Hakan Ozer |
| author_sort | Kader Zeybek Aydoğan |
| collection | DOAJ |
| description | Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR.
Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count.
Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria.
Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications. |
| first_indexed | 2024-03-12T01:29:46Z |
| format | Article |
| id | doaj.art-f0666d98f47241eca816ed1d3eeb0875 |
| institution | Directory Open Access Journal |
| issn | 2602-3741 |
| language | English |
| last_indexed | 2024-03-12T01:29:46Z |
| publishDate | 2023-08-01 |
| publisher | Selçuk University |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj.art-f0666d98f47241eca816ed1d3eeb08752023-09-12T06:31:27ZengSelçuk UniversityGenel Tıp Dergisi2602-37412023-08-0133438438910.54005/geneltip.1206894154Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?Kader Zeybek Aydoğan0İsmail Baloğlu1Fethi Yönet2Yasin Öztürk3Hakan Ozer4NIGDE OMER HALISDEMIR UNIVERSITY, SCHOOL OF MEDICINENECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINE, MERAM MEDICINE PR.NECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINE, MERAM MEDICINE PR.NECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINE, MERAM MEDICINE PR.NECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINE, MERAM MEDICINE PR.Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR. Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count. Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria. Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.https://dergipark.org.tr/tr/download/article-file/2781423albuminuriadiabetic nephropathyinflammationmonocyte-hdl cholesterol ratioalbüminüridiyabetik nefropatiinflamasyonmonosit-hdl kolesterol oranıalbüminüridiyabetik nefropatiinflamasyonmonosit-hdl kolesterol oranı |
| spellingShingle | Kader Zeybek Aydoğan İsmail Baloğlu Fethi Yönet Yasin Öztürk Hakan Ozer Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? Genel Tıp Dergisi albuminuria diabetic nephropathy inflammation monocyte-hdl cholesterol ratio albüminüri diyabetik nefropati inflamasyon monosit-hdl kolesterol oranı albüminüri diyabetik nefropati inflamasyon monosit-hdl kolesterol oranı |
| title | Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? |
| title_full | Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? |
| title_fullStr | Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? |
| title_full_unstemmed | Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? |
| title_short | Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy? |
| title_sort | monocyte hdl ratio can it be included in the follow up of diabetes mellitus and diagnosis of diabetic nephropathy |
| topic | albuminuria diabetic nephropathy inflammation monocyte-hdl cholesterol ratio albüminüri diyabetik nefropati inflamasyon monosit-hdl kolesterol oranı albüminüri diyabetik nefropati inflamasyon monosit-hdl kolesterol oranı |
| url | https://dergipark.org.tr/tr/download/article-file/2781423 |
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