Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs
<i>Background and Objectives</i>: Scant data regarding early post-COVID-19 effects are available, especially in younger people. Therefore, the objective of this study was to explore the early clinical impacts of post-COVID-19 pneumonia, comparing severe and non-severe patients. <i>...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/2/216 |
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| author | Nutchanok Niyatiwatchanchai Athavudh Deesomchok Warawut Chaiwong Pilaiporn Duangjit Chaicharn Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Theerakorn Theerakittikul Atikun Limsukon Pattraporn Tajarernmuang Konlawij Trongtrakul Juntima Euathrongchit Yutthaphan Wannasopha Tanop Srisuwan |
| author_facet | Nutchanok Niyatiwatchanchai Athavudh Deesomchok Warawut Chaiwong Pilaiporn Duangjit Chaicharn Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Theerakorn Theerakittikul Atikun Limsukon Pattraporn Tajarernmuang Konlawij Trongtrakul Juntima Euathrongchit Yutthaphan Wannasopha Tanop Srisuwan |
| author_sort | Nutchanok Niyatiwatchanchai |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Scant data regarding early post-COVID-19 effects are available, especially in younger people. Therefore, the objective of this study was to explore the early clinical impacts of post-COVID-19 pneumonia, comparing severe and non-severe patients. <i>Materials and Methods</i>: A cross-sectional study was conducted in adult patients admitted with COVID-19 pneumonia from April to May 2021. Demographic data, symptoms and signs, quality of life, Hospital Anxiety and Depression Scale (HADS), chest radiograph (CXR), pulmonary function tests (spirometry, impulse oscillometry), fractional exhaled nitric oxide (FeNO), and exercise capacity were assessed one month after hospital discharge. Twenty-five healthy control subjects that were age- and gender-matched were recruited for comparisons. <i>Results</i>: One hundred and five patients, with a mean age of 35.6 ± 15.8 years and 54 (51.4%) males, participated and were categorized into the non-severe pneumonia (N = 68) and severe pneumonia groups (N = 37). At a one-month follow-up visit (the time from the onset of the disease symptoms = 45.4 ± 5.9 days), the severe group had more cough, fatigue, and skin rash with higher dyspnea scale, more residual CXR lesions, and lower quality of life scores. Forced vital capacity (FVC) was lower in the severe group (88.3% of predicted value) and non-severe group (94.6% of predicted value) than in the healthy controls (<i>p</i> = 0.001). The six-minute walk distance was significantly lower in the non-severe group, at 79.2 m, and in the severe group, at 103.8 m, than in the healthy control subjects (<i>p</i> < 0.001). <i>Conclusions</i>: Adult patients with COVID-19, especially those with clinically severe pneumonia, still had residual symptoms and chest radiographic abnormalities, together with poorer quality of life and lower exercise capacity, one month after hospital discharge. |
| first_indexed | 2024-03-09T21:30:01Z |
| format | Article |
| id | doaj.art-f066d8a2fb00460b8cf47bdf615f7d64 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:30:01Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-f066d8a2fb00460b8cf47bdf615f7d642023-11-23T20:59:49ZengMDPI AGMedicina1010-660X1648-91442022-02-0158221610.3390/medicina58020216Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest RadiographsNutchanok Niyatiwatchanchai0Athavudh Deesomchok1Warawut Chaiwong2Pilaiporn Duangjit3Chaicharn Pothirat4Chalerm Liwsrisakun5Chaiwat Bumroongkit6Theerakorn Theerakittikul7Atikun Limsukon8Pattraporn Tajarernmuang9Konlawij Trongtrakul10Juntima Euathrongchit11Yutthaphan Wannasopha12Tanop Srisuwan13Division of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDivision of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawaroros Road Sriphum, Chiang Mai 50200, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand<i>Background and Objectives</i>: Scant data regarding early post-COVID-19 effects are available, especially in younger people. Therefore, the objective of this study was to explore the early clinical impacts of post-COVID-19 pneumonia, comparing severe and non-severe patients. <i>Materials and Methods</i>: A cross-sectional study was conducted in adult patients admitted with COVID-19 pneumonia from April to May 2021. Demographic data, symptoms and signs, quality of life, Hospital Anxiety and Depression Scale (HADS), chest radiograph (CXR), pulmonary function tests (spirometry, impulse oscillometry), fractional exhaled nitric oxide (FeNO), and exercise capacity were assessed one month after hospital discharge. Twenty-five healthy control subjects that were age- and gender-matched were recruited for comparisons. <i>Results</i>: One hundred and five patients, with a mean age of 35.6 ± 15.8 years and 54 (51.4%) males, participated and were categorized into the non-severe pneumonia (N = 68) and severe pneumonia groups (N = 37). At a one-month follow-up visit (the time from the onset of the disease symptoms = 45.4 ± 5.9 days), the severe group had more cough, fatigue, and skin rash with higher dyspnea scale, more residual CXR lesions, and lower quality of life scores. Forced vital capacity (FVC) was lower in the severe group (88.3% of predicted value) and non-severe group (94.6% of predicted value) than in the healthy controls (<i>p</i> = 0.001). The six-minute walk distance was significantly lower in the non-severe group, at 79.2 m, and in the severe group, at 103.8 m, than in the healthy control subjects (<i>p</i> < 0.001). <i>Conclusions</i>: Adult patients with COVID-19, especially those with clinically severe pneumonia, still had residual symptoms and chest radiographic abnormalities, together with poorer quality of life and lower exercise capacity, one month after hospital discharge.https://www.mdpi.com/1648-9144/58/2/216COVID-19lung functionexercise capacitychest radiographypneumoniamood disorders |
| spellingShingle | Nutchanok Niyatiwatchanchai Athavudh Deesomchok Warawut Chaiwong Pilaiporn Duangjit Chaicharn Pothirat Chalerm Liwsrisakun Chaiwat Bumroongkit Theerakorn Theerakittikul Atikun Limsukon Pattraporn Tajarernmuang Konlawij Trongtrakul Juntima Euathrongchit Yutthaphan Wannasopha Tanop Srisuwan Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs Medicina COVID-19 lung function exercise capacity chest radiography pneumonia mood disorders |
| title | Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs |
| title_full | Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs |
| title_fullStr | Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs |
| title_full_unstemmed | Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs |
| title_short | Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs |
| title_sort | comparative study of early impacts of post covid 19 pneumonia on clinical manifestations pulmonary function and chest radiographs |
| topic | COVID-19 lung function exercise capacity chest radiography pneumonia mood disorders |
| url | https://www.mdpi.com/1648-9144/58/2/216 |
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