Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease
Abstract Background Left heart failure (LHF) is commonly associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) but its role is often underestimated. Aim of study To evaluate the performance of a new diagnostic technique based on the measurement of the pulse amplitude r...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03089-y |
| _version_ | 1797865641878749184 |
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| author | Khaoula Bel Haj Ali Adel Sekma Ikram Chamtouri Kaouthar Beltaief Mohamed Amine Msolli Zied Mezgar Wahid Bouida Riadh Boukef Hamdi Boubaker Mohamed Habib Grissa Semir Nouira |
| author_facet | Khaoula Bel Haj Ali Adel Sekma Ikram Chamtouri Kaouthar Beltaief Mohamed Amine Msolli Zied Mezgar Wahid Bouida Riadh Boukef Hamdi Boubaker Mohamed Habib Grissa Semir Nouira |
| author_sort | Khaoula Bel Haj Ali |
| collection | DOAJ |
| description | Abstract Background Left heart failure (LHF) is commonly associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) but its role is often underestimated. Aim of study To evaluate the performance of a new diagnostic technique based on the measurement of the pulse amplitude ratio (PAR) using non-invasive ventilation (NIV) for the early identification LHF in patients admitted to the emergency department (ED) for AECOPD. Results 73 patients were included in this study: 32 in LHF group and 41 in non LHF- group. The two groups had comparable demographic and clinical characteristics at admission. The mean values of PARNIV was significantly higher among LHF patients (0.86 vs. 0.71; p < 0.01). The area under the receiver operating characteristic curve of PARNIV was 0.75. Using the best cut-off (0.6), the sensitivity of PARNIV was 93% with a specificity 21%, a positive predictive value of 48%, and a negative predictive value of 81%. Correlation between PARNIV and BNP was significant (r = 0.52; p = 0.002). Conclusion Measurement of PARNIV in patients presenting to the ED with AECOPD had a good diagnostic performance for the detection of LHF and could represent an interesting alternative for the currently available methods. Trial registration The study was registered in the Clinical Trial Registration System (clinicaltrials.gov) under the study number NCT05189119, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BOO4&selectaction=Edit&uid=U0000QAM&ts=2&cx=qrmluh . |
| first_indexed | 2024-04-09T23:12:31Z |
| format | Article |
| id | doaj.art-f06789522e5744b29668c9043aebc583 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T23:12:31Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f06789522e5744b29668c9043aebc5832023-03-22T10:22:33ZengBMCBMC Cardiovascular Disorders1471-22612023-02-012311810.1186/s12872-023-03089-yPulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary diseaseKhaoula Bel Haj Ali0Adel Sekma1Ikram Chamtouri2Kaouthar Beltaief3Mohamed Amine Msolli4Zied Mezgar5Wahid Bouida6Riadh Boukef7Hamdi Boubaker8Mohamed Habib Grissa9Semir Nouira10Emergency Department, Fattouma Bourguiba University HospitalEmergency Department, Fattouma Bourguiba University HospitalCardiology Department, Fattouma Bourguiba University HospitalEmergency Department, Fattouma Bourguiba University HospitalEmergency Department, Fattouma Bourguiba University HospitalEmergency Department, Farhat Hached University HospitalEmergency Department, Fattouma Bourguiba University HospitalResearch Laboratory LR12SP18, University of MonastirEmergency Department, Fattouma Bourguiba University HospitalEmergency Department, Fattouma Bourguiba University HospitalEmergency Department, Fattouma Bourguiba University HospitalAbstract Background Left heart failure (LHF) is commonly associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) but its role is often underestimated. Aim of study To evaluate the performance of a new diagnostic technique based on the measurement of the pulse amplitude ratio (PAR) using non-invasive ventilation (NIV) for the early identification LHF in patients admitted to the emergency department (ED) for AECOPD. Results 73 patients were included in this study: 32 in LHF group and 41 in non LHF- group. The two groups had comparable demographic and clinical characteristics at admission. The mean values of PARNIV was significantly higher among LHF patients (0.86 vs. 0.71; p < 0.01). The area under the receiver operating characteristic curve of PARNIV was 0.75. Using the best cut-off (0.6), the sensitivity of PARNIV was 93% with a specificity 21%, a positive predictive value of 48%, and a negative predictive value of 81%. Correlation between PARNIV and BNP was significant (r = 0.52; p = 0.002). Conclusion Measurement of PARNIV in patients presenting to the ED with AECOPD had a good diagnostic performance for the detection of LHF and could represent an interesting alternative for the currently available methods. Trial registration The study was registered in the Clinical Trial Registration System (clinicaltrials.gov) under the study number NCT05189119, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BOO4&selectaction=Edit&uid=U0000QAM&ts=2&cx=qrmluh .https://doi.org/10.1186/s12872-023-03089-yNon-invasive ventilationChronic obstructive pulmonary diseaseHeart failurePulse amplitude ratio |
| spellingShingle | Khaoula Bel Haj Ali Adel Sekma Ikram Chamtouri Kaouthar Beltaief Mohamed Amine Msolli Zied Mezgar Wahid Bouida Riadh Boukef Hamdi Boubaker Mohamed Habib Grissa Semir Nouira Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease BMC Cardiovascular Disorders Non-invasive ventilation Chronic obstructive pulmonary disease Heart failure Pulse amplitude ratio |
| title | Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| title_full | Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| title_fullStr | Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| title_full_unstemmed | Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| title_short | Pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| title_sort | pulse amplitude ratio under noninvasive ventilation as a new method in the diagnosis of left heart failure in patients with acute exacerbation of chronic obstructive pulmonary disease |
| topic | Non-invasive ventilation Chronic obstructive pulmonary disease Heart failure Pulse amplitude ratio |
| url | https://doi.org/10.1186/s12872-023-03089-y |
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