Postbiotics: emerging therapeutic approach in diabetic retinopathy
Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses a serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, and limited therapeutic effectiveness, it is extremely...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1359949/full |
| _version_ | 1797278877292167168 |
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| author | Qin Chen Qin Chen Xue-Jian Li Wei Xie Zhao-An Su Zhao-An Su Guang-Ming Qin Guang-Ming Qin Chen-Huan Yu Chen-Huan Yu |
| author_facet | Qin Chen Qin Chen Xue-Jian Li Wei Xie Zhao-An Su Zhao-An Su Guang-Ming Qin Guang-Ming Qin Chen-Huan Yu Chen-Huan Yu |
| author_sort | Qin Chen |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses a serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, and limited therapeutic effectiveness, it is extremely important to find a new strategy for the treatment of DR. Postbiotic is an emerging dietary supplement which consists of the inactivate microbiota and its metabolites. Numerous animal experiments have demonstrated that intervention with postbiotics reduces hyperglycemia, attenuates retinal peripapillary and endothelial cell damage, improves retinal microcirculatory dysfunction, and consequently delays the progression of DR. More strikingly, unlike conventional probiotics and prebiotics, postbiotics with small molecules can directly colonize the intestinal epithelial cells, and exert heat-resistant, acid-resistant, and durable for storage. Despite few clinical significance, oral administration with postbiotics might become the effective management for the prevention and treatment of DR. In this review, we summarized the basic conception, classification, molecular mechanisms, and the advances in the therapeutic implications of postbiotics in the pathogenesis of DR. Postbiotics present great potential as a viable adjunctive therapy for DR. |
| first_indexed | 2024-03-07T16:15:26Z |
| format | Article |
| id | doaj.art-f067cba478e5447a94506cc419cdd378 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-07T16:15:26Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f067cba478e5447a94506cc419cdd3782024-03-04T12:56:06ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-03-011510.3389/fmicb.2024.13599491359949Postbiotics: emerging therapeutic approach in diabetic retinopathyQin Chen0Qin Chen1Xue-Jian Li2Wei Xie3Zhao-An Su4Zhao-An Su5Guang-Ming Qin6Guang-Ming Qin7Chen-Huan Yu8Chen-Huan Yu9Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaKey Laboratory of Experimental Animal and Safety Evaluation, Hangzhou Medical College, Hangzhou, ChinaKey Laboratory of Experimental Animal and Safety Evaluation, Hangzhou Medical College, Hangzhou, ChinaEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaAnimal Laboratory Center, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, ChinaInstitute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, ChinaDiabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses a serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, and limited therapeutic effectiveness, it is extremely important to find a new strategy for the treatment of DR. Postbiotic is an emerging dietary supplement which consists of the inactivate microbiota and its metabolites. Numerous animal experiments have demonstrated that intervention with postbiotics reduces hyperglycemia, attenuates retinal peripapillary and endothelial cell damage, improves retinal microcirculatory dysfunction, and consequently delays the progression of DR. More strikingly, unlike conventional probiotics and prebiotics, postbiotics with small molecules can directly colonize the intestinal epithelial cells, and exert heat-resistant, acid-resistant, and durable for storage. Despite few clinical significance, oral administration with postbiotics might become the effective management for the prevention and treatment of DR. In this review, we summarized the basic conception, classification, molecular mechanisms, and the advances in the therapeutic implications of postbiotics in the pathogenesis of DR. Postbiotics present great potential as a viable adjunctive therapy for DR.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1359949/fullpostbioticgut-retinal axisshort chain fatty acidssecondary bile acidssafety |
| spellingShingle | Qin Chen Qin Chen Xue-Jian Li Wei Xie Zhao-An Su Zhao-An Su Guang-Ming Qin Guang-Ming Qin Chen-Huan Yu Chen-Huan Yu Postbiotics: emerging therapeutic approach in diabetic retinopathy Frontiers in Microbiology postbiotic gut-retinal axis short chain fatty acids secondary bile acids safety |
| title | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| title_full | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| title_fullStr | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| title_full_unstemmed | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| title_short | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| title_sort | postbiotics emerging therapeutic approach in diabetic retinopathy |
| topic | postbiotic gut-retinal axis short chain fatty acids secondary bile acids safety |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1359949/full |
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