Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic fibroblast-like cells which play important roles in tissue repair, inflammation, and immune modulation. MSCs residing in the bone marrow microenvironment (BMME) functionally interact with hematopoietic stem progenitor...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/12/1701 |
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| author | Sebastiano Giallongo Andrea Duminuco Ilaria Dulcamare Tatiana Zuppelli Enrico La Spina Grazia Scandura Annalisa Santisi Alessandra Romano Francesco Di Raimondo Daniele Tibullo Giuseppe A. Palumbo Cesarina Giallongo |
| author_facet | Sebastiano Giallongo Andrea Duminuco Ilaria Dulcamare Tatiana Zuppelli Enrico La Spina Grazia Scandura Annalisa Santisi Alessandra Romano Francesco Di Raimondo Daniele Tibullo Giuseppe A. Palumbo Cesarina Giallongo |
| author_sort | Sebastiano Giallongo |
| collection | DOAJ |
| description | Mesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic fibroblast-like cells which play important roles in tissue repair, inflammation, and immune modulation. MSCs residing in the bone marrow microenvironment (BMME) functionally interact with hematopoietic stem progenitor cells regulating hematopoiesis. However, MSCs have also emerged in recent years as key regulators of the tumor microenvironment. Indeed, they are now considered active players in the pathophysiology of hematologic malignancies rather than passive bystanders in the hematopoietic microenvironment. Once a malignant event occurs, the BMME acquires cellular, molecular, and epigenetic abnormalities affecting tumor growth and progression. In this context, MSC behavior is affected by signals coming from cancer cells. Furthermore, it has been shown that stromal cells themselves play a major role in several hematological malignancies’ pathogenesis. This bidirectional crosstalk creates a functional tumor niche unit wherein tumor cells acquire a selective advantage over their normal counterparts and are protected from drug treatment. It is therefore of critical importance to unveil the underlying mechanisms which activate a protumor phenotype of MSCs for defining the unmasked vulnerabilities of hematological cancer cells which could be pharmacologically exploited to disrupt tumor/MSC coupling. The present review focuses on the current knowledge about MSC dysfunction mechanisms in the BMME of hematological cancers, sustaining tumor growth, immune escape, and cancer progression. |
| first_indexed | 2024-03-08T20:58:14Z |
| format | Article |
| id | doaj.art-f06c1d0e30b044c891ee8a30f6dffaf2 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-08T20:58:14Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f06c1d0e30b044c891ee8a30f6dffaf22023-12-22T13:55:49ZengMDPI AGBiomolecules2218-273X2023-11-011312170110.3390/biom13121701Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological CancersSebastiano Giallongo0Andrea Duminuco1Ilaria Dulcamare2Tatiana Zuppelli3Enrico La Spina4Grazia Scandura5Annalisa Santisi6Alessandra Romano7Francesco Di Raimondo8Daniele Tibullo9Giuseppe A. Palumbo10Cesarina Giallongo11Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, ItalyDivision of Hematology, AOU Policlinico, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, ItalyDivision of Hematology, AOU Policlinico, 95123 Catania, ItalyDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, ItalyDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, ItalyDepartment of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, ItalyMesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic fibroblast-like cells which play important roles in tissue repair, inflammation, and immune modulation. MSCs residing in the bone marrow microenvironment (BMME) functionally interact with hematopoietic stem progenitor cells regulating hematopoiesis. However, MSCs have also emerged in recent years as key regulators of the tumor microenvironment. Indeed, they are now considered active players in the pathophysiology of hematologic malignancies rather than passive bystanders in the hematopoietic microenvironment. Once a malignant event occurs, the BMME acquires cellular, molecular, and epigenetic abnormalities affecting tumor growth and progression. In this context, MSC behavior is affected by signals coming from cancer cells. Furthermore, it has been shown that stromal cells themselves play a major role in several hematological malignancies’ pathogenesis. This bidirectional crosstalk creates a functional tumor niche unit wherein tumor cells acquire a selective advantage over their normal counterparts and are protected from drug treatment. It is therefore of critical importance to unveil the underlying mechanisms which activate a protumor phenotype of MSCs for defining the unmasked vulnerabilities of hematological cancer cells which could be pharmacologically exploited to disrupt tumor/MSC coupling. The present review focuses on the current knowledge about MSC dysfunction mechanisms in the BMME of hematological cancers, sustaining tumor growth, immune escape, and cancer progression.https://www.mdpi.com/2218-273X/13/12/1701MSCstumor transformationhematological cancerssenescenceinflammation |
| spellingShingle | Sebastiano Giallongo Andrea Duminuco Ilaria Dulcamare Tatiana Zuppelli Enrico La Spina Grazia Scandura Annalisa Santisi Alessandra Romano Francesco Di Raimondo Daniele Tibullo Giuseppe A. Palumbo Cesarina Giallongo Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers Biomolecules MSCs tumor transformation hematological cancers senescence inflammation |
| title | Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers |
| title_full | Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers |
| title_fullStr | Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers |
| title_full_unstemmed | Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers |
| title_short | Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers |
| title_sort | engagement of mesenchymal stromal cells in the remodeling of the bone marrow microenvironment in hematological cancers |
| topic | MSCs tumor transformation hematological cancers senescence inflammation |
| url | https://www.mdpi.com/2218-273X/13/12/1701 |
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