Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria
Background: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated wit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Nigerian Postgraduate Medical Journal |
| Subjects: | |
| Online Access: | http://www.npmj.org/article.asp?issn=1117-1936;year=2017;volume=24;issue=2;spage=88;epage=92;aulast=Olumuyiwa |
| _version_ | 1819124571486289920 |
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| author | J Fasipe Olumuyiwa A Akinbodewa Akinwumi O Adejumo Ademola B Akawa Oluwole E Okaka Ibiene |
| author_facet | J Fasipe Olumuyiwa A Akinbodewa Akinwumi O Adejumo Ademola B Akawa Oluwole E Okaka Ibiene |
| author_sort | J Fasipe Olumuyiwa |
| collection | DOAJ |
| description | Background: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. Objectives: This study determined the prevalence and pattern of potential DDIs among CKD patients attending Kidney Care Centre, in Ondo City, Nigeria. Methodology: It was an 18-month retrospective study that involved the reviewed CKD patients' records. The Lexi-Interact database was used to evaluate patients' medications for potential DDIs. Results: One hundred and twenty-three (123) CKD patients, made up of 82 (66.67%) males and 41 (33.33%) females were studied. The mean age of the CKD patients was 53.81 ± 16.03 years. The most common comorbid conditions were hypertension in 103 (83.74%) and diabetes mellitus in 39 (31.71%). A total of 1237 prescriptions were made and the mean number of prescribed medications per patient was 10.06 ± 3.97. A total number of 1851 potential DDIs were observed among 118 patients. The prevalence of potential DDIs was 95.9% while the mean DDIs per prescription was 1.27. Among the potential DDIs observed, the severity was mild in 639 (34.5%), moderate in 1160 (62.7%), major in 51 (2.8%) and only 1 (0.1%) was of avoid drug combination. The most frequent DDI was between calcium carbonate and oral ferrous sulphate. Conclusion: The prevalence of potential DDIs is high among CKD patients. About 63% of these interactions have moderate severity. Clinicians and pharmacists should utilise available DDI software to avoid harmful DDIs in CKD patients. |
| first_indexed | 2024-12-22T07:26:22Z |
| format | Article |
| id | doaj.art-f06d97ed2571429b852db4897d39bec8 |
| institution | Directory Open Access Journal |
| issn | 1117-1936 2468-6875 |
| language | English |
| last_indexed | 2024-12-22T07:26:22Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Postgraduate Medical Journal |
| spelling | doaj.art-f06d97ed2571429b852db4897d39bec82022-12-21T18:34:08ZengWolters Kluwer Medknow PublicationsNigerian Postgraduate Medical Journal1117-19362468-68752017-01-01242889210.4103/npmj.npmj_64_17Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western NigeriaJ Fasipe OlumuyiwaA Akinbodewa AkinwumiO Adejumo AdemolaB Akawa OluwoleE Okaka IbieneBackground: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. Objectives: This study determined the prevalence and pattern of potential DDIs among CKD patients attending Kidney Care Centre, in Ondo City, Nigeria. Methodology: It was an 18-month retrospective study that involved the reviewed CKD patients' records. The Lexi-Interact database was used to evaluate patients' medications for potential DDIs. Results: One hundred and twenty-three (123) CKD patients, made up of 82 (66.67%) males and 41 (33.33%) females were studied. The mean age of the CKD patients was 53.81 ± 16.03 years. The most common comorbid conditions were hypertension in 103 (83.74%) and diabetes mellitus in 39 (31.71%). A total of 1237 prescriptions were made and the mean number of prescribed medications per patient was 10.06 ± 3.97. A total number of 1851 potential DDIs were observed among 118 patients. The prevalence of potential DDIs was 95.9% while the mean DDIs per prescription was 1.27. Among the potential DDIs observed, the severity was mild in 639 (34.5%), moderate in 1160 (62.7%), major in 51 (2.8%) and only 1 (0.1%) was of avoid drug combination. The most frequent DDI was between calcium carbonate and oral ferrous sulphate. Conclusion: The prevalence of potential DDIs is high among CKD patients. About 63% of these interactions have moderate severity. Clinicians and pharmacists should utilise available DDI software to avoid harmful DDIs in CKD patients.http://www.npmj.org/article.asp?issn=1117-1936;year=2017;volume=24;issue=2;spage=88;epage=92;aulast=Olumuyiwachronic kidney diseasedrug-drug interactionspatternpotentialprevalence |
| spellingShingle | J Fasipe Olumuyiwa A Akinbodewa Akinwumi O Adejumo Ademola B Akawa Oluwole E Okaka Ibiene Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria Nigerian Postgraduate Medical Journal chronic kidney disease drug-drug interactions pattern potential prevalence |
| title | Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria |
| title_full | Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria |
| title_fullStr | Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria |
| title_full_unstemmed | Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria |
| title_short | Prevalence and pattern of potential drug-drug interactions among chronic kidney disease patients in south-western Nigeria |
| title_sort | prevalence and pattern of potential drug drug interactions among chronic kidney disease patients in south western nigeria |
| topic | chronic kidney disease drug-drug interactions pattern potential prevalence |
| url | http://www.npmj.org/article.asp?issn=1117-1936;year=2017;volume=24;issue=2;spage=88;epage=92;aulast=Olumuyiwa |
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