The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications
Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13685 |
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| author | Ilaria Mormile Fabiana Tuccillo Francesca Della Casa Valentina D’Aiuto Nunzia Montuori Marina De Rosa Filomena Napolitano Amato de Paulis Francesca Wanda Rossi |
| author_facet | Ilaria Mormile Fabiana Tuccillo Francesca Della Casa Valentina D’Aiuto Nunzia Montuori Marina De Rosa Filomena Napolitano Amato de Paulis Francesca Wanda Rossi |
| author_sort | Ilaria Mormile |
| collection | DOAJ |
| description | Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration. |
| first_indexed | 2024-03-10T22:41:44Z |
| format | Article |
| id | doaj.art-f06da9f1f59c49dd9759cdf54cc89867 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:41:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f06da9f1f59c49dd9759cdf54cc898672023-11-19T11:01:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181368510.3390/ijms241813685The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical ApplicationsIlaria Mormile0Fabiana Tuccillo1Francesca Della Casa2Valentina D’Aiuto3Nunzia Montuori4Marina De Rosa5Filomena Napolitano6Amato de Paulis7Francesca Wanda Rossi8Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Law, University of Naples Federico II, 80138 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyPost-Graduate Program in Clinical Immunology and Allergy, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyNatural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration.https://www.mdpi.com/1422-0067/24/18/13685Nitrodispringthermalismwound healingbalneotherapywater |
| spellingShingle | Ilaria Mormile Fabiana Tuccillo Francesca Della Casa Valentina D’Aiuto Nunzia Montuori Marina De Rosa Filomena Napolitano Amato de Paulis Francesca Wanda Rossi The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications International Journal of Molecular Sciences Nitrodi spring thermalism wound healing balneotherapy water |
| title | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
| title_full | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
| title_fullStr | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
| title_full_unstemmed | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
| title_short | The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications |
| title_sort | benefits of water from nitrodi s spring the in vitro studies leading the potential clinical applications |
| topic | Nitrodi spring thermalism wound healing balneotherapy water |
| url | https://www.mdpi.com/1422-0067/24/18/13685 |
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