Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00477-9 |
| _version_ | 1818433809552506880 |
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| author | Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia |
| author_facet | Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia |
| author_sort | Longfa Xu |
| collection | DOAJ |
| description | Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development. |
| first_indexed | 2024-12-14T16:27:00Z |
| format | Article |
| id | doaj.art-f06de03619794e4cae31c9264a758c1f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:27:00Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f06de03619794e4cae31c9264a758c1f2022-12-21T22:54:40ZengNature PortfolioNature Communications2041-17232017-09-018111210.1038/s41467-017-00477-9Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibodyLongfa Xu0Qingbing Zheng1Shaowei Li2Maozhou He3Yangtao Wu4Yongchao Li5Rui Zhu6Hai Yu7Qiyang Hong8Jie Jiang9Zizhen Li10Shuxuan Li11Huan Zhao12Lisheng Yang13Wangheng Hou14Wei Wang15Xiangzhong Ye16Jun Zhang17Timothy S. Baker18Tong Cheng19Z. Hong Zhou20Xiaodong Yan21Ningshao Xia22State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityDepartment of Research & Development Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityDepartment of Research & Development Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityDepartment of Chemistry and Biochemistry and Division of Biological Sciences, University of California-San DiegoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityThe California NanoSystems Institute (CNSI), UCLAState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen UniversityCoxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.https://doi.org/10.1038/s41467-017-00477-9 |
| spellingShingle | Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody Nature Communications |
| title | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_full | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_fullStr | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_full_unstemmed | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_short | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_sort | atomic structures of coxsackievirus a6 and its complex with a neutralizing antibody |
| url | https://doi.org/10.1038/s41467-017-00477-9 |
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