The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs

The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs

G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to their pathophysiological significance and pharmacological relevance. Class A receptors represent the largest group of GPCRs that gives the highest number of validated drug targets. Endogenous ligands bind to the...

Full description

Bibliographic Details
Main Authors: Attila Egyed, Dóra Judit Kiss, György M. Keserű
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
GPCR (G-protein coupled receptor)
allosteric
bitopic
selectivity
functional selectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.847788/full

Similar Items

Similar Items