Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models

Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models

Abstract Background Evaluation of parasite clearance patterns in experimental human infection trials helps increase understanding of drug action. In a previously reported phase Ib trial of a new investigational anti-malarial drug M5717, parasite clearance showed a biphasic linear pattern: slow remov...

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Bibliographic Details
Main Authors: Xiaoyan Yin, Ying Li, Wilhelmina Bagchus, Özkan Yalkinoglu, Deon Bezuidenhout, Aliona Tappert, James McCarthy, Louise Marquart, Claude Oeuvray
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Malaria Journal
Subjects:
Parasite clearance
Segmented mixed model
Malaria
Online Access:https://doi.org/10.1186/s12936-023-04627-x

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