The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer
Gastric cancer (GC) is one of the most common malignancies in the world. Exosomes, a subset of extracellular vesicles with an average diameter of 100 nm, contain and transfer a variety of functional macromolecules such as proteins, lipids, and nucleic acids. A large number of studies indicated that...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/1/73 |
| _version_ | 1797414695627390976 |
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| author | Guiping Zhao Anni Zhou Xiao Li Shengtao Zhu Yongjun Wang Shutian Zhang Peng Li |
| author_facet | Guiping Zhao Anni Zhou Xiao Li Shengtao Zhu Yongjun Wang Shutian Zhang Peng Li |
| author_sort | Guiping Zhao |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most common malignancies in the world. Exosomes, a subset of extracellular vesicles with an average diameter of 100 nm, contain and transfer a variety of functional macromolecules such as proteins, lipids, and nucleic acids. A large number of studies indicated that exosomes can play a significant role in the initiation and development of GC via facilitating intercellular communication between gastric cancer cells and microenvironment. Exosomal RNAs, one of the key functional cargos, are involved in the pathogenesis, development, and metastasis of GC. In addition, recent studies elucidated that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for GC. In this review, we summarized the function of exosomal RNA in the tumorigenesis, progression, diagnosis, and treatment of GC, which may further unveil the functions of exosome and promote the potentially diagnostic and therapeutic application of exosomes in GC. |
| first_indexed | 2024-03-09T05:37:17Z |
| format | Article |
| id | doaj.art-f070666ebc974c31a77ebb290414f9e0 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T05:37:17Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-f070666ebc974c31a77ebb290414f9e02023-12-03T12:28:31ZengMDPI AGGenes2073-44252021-01-011217310.3390/genes12010073The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric CancerGuiping Zhao0Anni Zhou1Xiao Li2Shengtao Zhu3Yongjun Wang4Shutian Zhang5Peng Li6Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaGastric cancer (GC) is one of the most common malignancies in the world. Exosomes, a subset of extracellular vesicles with an average diameter of 100 nm, contain and transfer a variety of functional macromolecules such as proteins, lipids, and nucleic acids. A large number of studies indicated that exosomes can play a significant role in the initiation and development of GC via facilitating intercellular communication between gastric cancer cells and microenvironment. Exosomal RNAs, one of the key functional cargos, are involved in the pathogenesis, development, and metastasis of GC. In addition, recent studies elucidated that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for GC. In this review, we summarized the function of exosomal RNA in the tumorigenesis, progression, diagnosis, and treatment of GC, which may further unveil the functions of exosome and promote the potentially diagnostic and therapeutic application of exosomes in GC.https://www.mdpi.com/2073-4425/12/1/73exosomeexosomal RNAsgastric cancerbiomarker |
| spellingShingle | Guiping Zhao Anni Zhou Xiao Li Shengtao Zhu Yongjun Wang Shutian Zhang Peng Li The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer Genes exosome exosomal RNAs gastric cancer biomarker |
| title | The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer |
| title_full | The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer |
| title_fullStr | The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer |
| title_full_unstemmed | The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer |
| title_short | The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer |
| title_sort | significance of exosomal rnas in the development diagnosis and treatment of gastric cancer |
| topic | exosome exosomal RNAs gastric cancer biomarker |
| url | https://www.mdpi.com/2073-4425/12/1/73 |
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