Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review
Justin J Kuhlman,1 Muhamad Alhaj Moustafa,2 Vivek Gupta,3 Liuyan Jiang,4 Han W Tun2 1Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA; 2Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA; 3Department of Radiology, Mayo Clinic Florida, J...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-07-01
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| Series: | Journal of Blood Medicine |
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| Online Access: | https://www.dovepress.com/primary-cauda-equina-lymphoma-treated-with-cns-centric-approach-a-case-peer-reviewed-fulltext-article-JBM |
| _version_ | 1818455144175501312 |
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| author | Kuhlman JJ Alhaj Moustafa M Gupta V Jiang L Tun HW |
| author_facet | Kuhlman JJ Alhaj Moustafa M Gupta V Jiang L Tun HW |
| author_sort | Kuhlman JJ |
| collection | DOAJ |
| description | Justin J Kuhlman,1 Muhamad Alhaj Moustafa,2 Vivek Gupta,3 Liuyan Jiang,4 Han W Tun2 1Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA; 2Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA; 3Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA; 4Department of Pathology and Laboratory Medicine, Jacksonville, FL, USACorrespondence: Han W TunMayo Clinic Florida, Division of Hematology and Oncology, 4500 San Pablo Road S, Jacksonville, FL, 32224, USATel +1 904-953-2000Email tun.han@mayo.eduAbstract: Primary cauda equina lymphoma is an extremely rare entity previously documented in only 24 reported cases. Primary cauda equina lymphoma represents a subtype of neurolymphomatosis, which occurs when lymphoma cells with neurotropism infiltrate and destroy peripheral nerves, spinal nerve roots, nerve plexuses and cranial nerves. The cauda equina is an anatomic structure located in the lower part of the spinal canal consisting of multiple lumbar and sacral nerve roots. Herein, we report a unique case of primary cauda equina diffuse large B-cell lymphoma presenting as a tumor mass in the lower spinal canal, which was treated with a CNS-centric treatment approach followed by autologous hematopoietic stem cell transplantation.Keywords: primary cauda equina lymphoma, neurolymphomatosis, diffuse large B cell cauda equina lymphoma, MATRIX chemoimmunotherapy, autologous stem cell transplant |
| first_indexed | 2024-12-14T22:06:06Z |
| format | Article |
| id | doaj.art-f0727b47d43848679891848e9964bb73 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-14T22:06:06Z |
| publishDate | 2021-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-f0727b47d43848679891848e9964bb732022-12-21T22:45:52ZengDove Medical PressJournal of Blood Medicine1179-27362021-07-01Volume 1264565267160Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature ReviewKuhlman JJAlhaj Moustafa MGupta VJiang LTun HWJustin J Kuhlman,1 Muhamad Alhaj Moustafa,2 Vivek Gupta,3 Liuyan Jiang,4 Han W Tun2 1Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA; 2Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA; 3Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA; 4Department of Pathology and Laboratory Medicine, Jacksonville, FL, USACorrespondence: Han W TunMayo Clinic Florida, Division of Hematology and Oncology, 4500 San Pablo Road S, Jacksonville, FL, 32224, USATel +1 904-953-2000Email tun.han@mayo.eduAbstract: Primary cauda equina lymphoma is an extremely rare entity previously documented in only 24 reported cases. Primary cauda equina lymphoma represents a subtype of neurolymphomatosis, which occurs when lymphoma cells with neurotropism infiltrate and destroy peripheral nerves, spinal nerve roots, nerve plexuses and cranial nerves. The cauda equina is an anatomic structure located in the lower part of the spinal canal consisting of multiple lumbar and sacral nerve roots. Herein, we report a unique case of primary cauda equina diffuse large B-cell lymphoma presenting as a tumor mass in the lower spinal canal, which was treated with a CNS-centric treatment approach followed by autologous hematopoietic stem cell transplantation.Keywords: primary cauda equina lymphoma, neurolymphomatosis, diffuse large B cell cauda equina lymphoma, MATRIX chemoimmunotherapy, autologous stem cell transplanthttps://www.dovepress.com/primary-cauda-equina-lymphoma-treated-with-cns-centric-approach-a-case-peer-reviewed-fulltext-article-JBMprimary cauda equina lymphomaneurolymphomatosisdiffuse large b cell cauda equina lymphomamatrix chemoimmunotherapyautologous stem cell transplant |
| spellingShingle | Kuhlman JJ Alhaj Moustafa M Gupta V Jiang L Tun HW Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review Journal of Blood Medicine primary cauda equina lymphoma neurolymphomatosis diffuse large b cell cauda equina lymphoma matrix chemoimmunotherapy autologous stem cell transplant |
| title | Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review |
| title_full | Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review |
| title_fullStr | Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review |
| title_full_unstemmed | Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review |
| title_short | Primary Cauda Equina Lymphoma Treated with CNS-Centric Approach: A Case Report and Literature Review |
| title_sort | primary cauda equina lymphoma treated with cns centric approach a case report and literature review |
| topic | primary cauda equina lymphoma neurolymphomatosis diffuse large b cell cauda equina lymphoma matrix chemoimmunotherapy autologous stem cell transplant |
| url | https://www.dovepress.com/primary-cauda-equina-lymphoma-treated-with-cns-centric-approach-a-case-peer-reviewed-fulltext-article-JBM |
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