miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway

miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway

Abstract Background MicroRNAs (miRNAs) play crucial roles in tumor initiation and development. Previously, we indicated that miR-504 is downregulated and suppresses tumor proliferation in glioblastoma (GBM). However, the regulation and relevant mechanism of miR-504 in GBM mesenchymal (ME) transition...

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Bibliographic Details
Main Authors: Qiang Liu, Yanlei Guan, Zhenhang Li, Yao Wang, Yu Liu, Run Cui, Yunjie Wang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
GBM
miR-504
Mesenchymal phenotype
EMT
FZD7
Wnt–β-catenin pathway
Online Access:http://link.springer.com/article/10.1186/s13046-019-1370-1

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