Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa
The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary scenario, new rodent-derived, whole LASV sequences were included. These were generated by metatranscrip...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2290834 |
| _version_ | 1826951969370013696 |
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| author | Umaru Bangura Christopher Davis Joyce Lamin James Bangura Barré Soropogui Andrew J. Davison Jenna Nichols Matej Vucak Mickael Dawson Rashid Ansumana Dianah Sondufu Dániel Cadar Toni Rieger Emma Thomson Foday Sahr N’Faly Magassouba Bruno Ghersi Brian H. Bird Elisabeth Fichet-Calvet |
| author_facet | Umaru Bangura Christopher Davis Joyce Lamin James Bangura Barré Soropogui Andrew J. Davison Jenna Nichols Matej Vucak Mickael Dawson Rashid Ansumana Dianah Sondufu Dániel Cadar Toni Rieger Emma Thomson Foday Sahr N’Faly Magassouba Bruno Ghersi Brian H. Bird Elisabeth Fichet-Calvet |
| author_sort | Umaru Bangura |
| collection | DOAJ |
| description | The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary scenario, new rodent-derived, whole LASV sequences were included. These were generated by metatranscriptomic next-generation sequencing from rodents sampled between 2003 and 2020 in 21 localities of Guinea and Sierra Leone. An analysis was performed using BEAST to perform continuous phylogeographic inference and EvoLaps v36 to visualize spatio-temporal spread. LASV was identified as expected in its primary host reservoir, the Natal multimammate mouse (Mastomys natalensis), and also in two Guinean multimammate mice (Mastomys erythroleucus) in northern Sierra Leone and two rusty-bellied brush-furred mice (Lophuromys sikapusi) in southern Sierra Leone. This finding is consistent with the latter two species being secondary host reservoirs. The strains in these three species were very closely related in LASV lineage IV. Phylogenetic analysis indicated that the most recent common ancestor of lineage IV existed 316–374 years ago and revealed distinct, well-supported clades from Sierra Leone (Bo, Kabala and Kenema), Guinea (Faranah, Kissidougou-Guekedou and Macenta) and Liberia (Phebe-Ganta). The phylogeographic scenario suggests southern Guinea as the point of origin of LASV in the MRU area, with subsequent spread to towards Mali, Liberia and Sierra Leone at a mean speed of 1.6 to 1.1 km/year. |
| first_indexed | 2024-03-07T14:07:24Z |
| format | Article |
| id | doaj.art-f073532beaad435cb352b3ea2b618355 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2025-02-17T22:59:59Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-f073532beaad435cb352b3ea2b6183552024-12-02T10:52:49ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2290834Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West AfricaUmaru Bangura0Christopher Davis1Joyce Lamin2James Bangura3Barré Soropogui4Andrew J. Davison5Jenna Nichols6Matej Vucak7Mickael Dawson8Rashid Ansumana9Dianah Sondufu10Dániel Cadar11Toni Rieger12Emma Thomson13Foday Sahr14N’Faly Magassouba15Bruno Ghersi16Brian H. Bird17Elisabeth Fichet-Calvet18Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, GermanyMRC-University of Glasgow Centre for Virus Research, Glasgow, UKMercy Hospital Research Laboratory, Bo, Sierra LeoneUniversity of Makeni and University of California, Davis One Health Program, Makeni, Sierra LeoneLaboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaMRC-University of Glasgow Centre for Virus Research, Glasgow, UKMRC-University of Glasgow Centre for Virus Research, Glasgow, UKMRC-University of Glasgow Centre for Virus Research, Glasgow, UKMercy Hospital Research Laboratory, Bo, Sierra LeoneMercy Hospital Research Laboratory, Bo, Sierra LeoneMercy Hospital Research Laboratory, Bo, Sierra LeoneBernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, GermanyBernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, GermanyMRC-University of Glasgow Centre for Virus Research, Glasgow, UKCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra LeoneLaboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaOne Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, USAOne Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, USABernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, GermanyThe spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary scenario, new rodent-derived, whole LASV sequences were included. These were generated by metatranscriptomic next-generation sequencing from rodents sampled between 2003 and 2020 in 21 localities of Guinea and Sierra Leone. An analysis was performed using BEAST to perform continuous phylogeographic inference and EvoLaps v36 to visualize spatio-temporal spread. LASV was identified as expected in its primary host reservoir, the Natal multimammate mouse (Mastomys natalensis), and also in two Guinean multimammate mice (Mastomys erythroleucus) in northern Sierra Leone and two rusty-bellied brush-furred mice (Lophuromys sikapusi) in southern Sierra Leone. This finding is consistent with the latter two species being secondary host reservoirs. The strains in these three species were very closely related in LASV lineage IV. Phylogenetic analysis indicated that the most recent common ancestor of lineage IV existed 316–374 years ago and revealed distinct, well-supported clades from Sierra Leone (Bo, Kabala and Kenema), Guinea (Faranah, Kissidougou-Guekedou and Macenta) and Liberia (Phebe-Ganta). The phylogeographic scenario suggests southern Guinea as the point of origin of LASV in the MRU area, with subsequent spread to towards Mali, Liberia and Sierra Leone at a mean speed of 1.6 to 1.1 km/year.https://www.tandfonline.com/doi/10.1080/22221751.2023.2290834Lassa virusspreadphylogeographyrodentLophuromys sikapusiGuinea |
| spellingShingle | Umaru Bangura Christopher Davis Joyce Lamin James Bangura Barré Soropogui Andrew J. Davison Jenna Nichols Matej Vucak Mickael Dawson Rashid Ansumana Dianah Sondufu Dániel Cadar Toni Rieger Emma Thomson Foday Sahr N’Faly Magassouba Bruno Ghersi Brian H. Bird Elisabeth Fichet-Calvet Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa Emerging Microbes and Infections Lassa virus spread phylogeography rodent Lophuromys sikapusi Guinea |
| title | Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa |
| title_full | Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa |
| title_fullStr | Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa |
| title_full_unstemmed | Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa |
| title_short | Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa |
| title_sort | spatio temporal spread of lassa virus and a new rodent host in the mano river union area west africa |
| topic | Lassa virus spread phylogeography rodent Lophuromys sikapusi Guinea |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2290834 |
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