Aurora A and AKT Kinase Signaling Associated with Primary Cilia
Dysregulation of kinase signaling is associated with various pathological conditions, including cancer, inflammation, and autoimmunity; consequently, the kinases involved have become major therapeutic targets. While kinase signaling pathways play crucial roles in multiple cellular processes, the pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3602 |
| _version_ | 1797505929659285504 |
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| author | Yuhei Nishimura Daishi Yamakawa Takashi Shiromizu Masaki Inagaki |
| author_facet | Yuhei Nishimura Daishi Yamakawa Takashi Shiromizu Masaki Inagaki |
| author_sort | Yuhei Nishimura |
| collection | DOAJ |
| description | Dysregulation of kinase signaling is associated with various pathological conditions, including cancer, inflammation, and autoimmunity; consequently, the kinases involved have become major therapeutic targets. While kinase signaling pathways play crucial roles in multiple cellular processes, the precise manner in which their dysregulation contributes to disease is dependent on the context; for example, the cell/tissue type or subcellular localization of the kinase or substrate. Thus, context-selective targeting of dysregulated kinases may serve to increase the therapeutic specificity while reducing off-target adverse effects. Primary cilia are antenna-like structures that extend from the plasma membrane and function by detecting extracellular cues and transducing signals into the cell. Cilia formation and signaling are dynamically regulated through context-dependent mechanisms; as such, dysregulation of primary cilia contributes to disease in a variety of ways. Here, we review the involvement of primary cilia-associated signaling through aurora A and AKT kinases with respect to cancer, obesity, and other ciliopathies. |
| first_indexed | 2024-03-10T04:25:21Z |
| format | Article |
| id | doaj.art-f073b227ee56419c8064498617e06a99 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:21Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f073b227ee56419c8064498617e06a992023-11-23T07:40:04ZengMDPI AGCells2073-44092021-12-011012360210.3390/cells10123602Aurora A and AKT Kinase Signaling Associated with Primary CiliaYuhei Nishimura0Daishi Yamakawa1Takashi Shiromizu2Masaki Inagaki3Department of Integrative Pharmacology, Graduate School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Physiology, Graduate School of Medicine, Mie University, Tsu 514-8507, JapanDepartment of Integrative Pharmacology, Graduate School of Medicine, Mie University, Tsu 514-8507, JapanGlocal Research Center for Advanced Medical Science, Mie University, Tsu 514-8507, JapanDysregulation of kinase signaling is associated with various pathological conditions, including cancer, inflammation, and autoimmunity; consequently, the kinases involved have become major therapeutic targets. While kinase signaling pathways play crucial roles in multiple cellular processes, the precise manner in which their dysregulation contributes to disease is dependent on the context; for example, the cell/tissue type or subcellular localization of the kinase or substrate. Thus, context-selective targeting of dysregulated kinases may serve to increase the therapeutic specificity while reducing off-target adverse effects. Primary cilia are antenna-like structures that extend from the plasma membrane and function by detecting extracellular cues and transducing signals into the cell. Cilia formation and signaling are dynamically regulated through context-dependent mechanisms; as such, dysregulation of primary cilia contributes to disease in a variety of ways. Here, we review the involvement of primary cilia-associated signaling through aurora A and AKT kinases with respect to cancer, obesity, and other ciliopathies.https://www.mdpi.com/2073-4409/10/12/3602primary ciliumaurora kinase AAKT kinasetrichopleinlipid raftproliferation |
| spellingShingle | Yuhei Nishimura Daishi Yamakawa Takashi Shiromizu Masaki Inagaki Aurora A and AKT Kinase Signaling Associated with Primary Cilia Cells primary cilium aurora kinase A AKT kinase trichoplein lipid raft proliferation |
| title | Aurora A and AKT Kinase Signaling Associated with Primary Cilia |
| title_full | Aurora A and AKT Kinase Signaling Associated with Primary Cilia |
| title_fullStr | Aurora A and AKT Kinase Signaling Associated with Primary Cilia |
| title_full_unstemmed | Aurora A and AKT Kinase Signaling Associated with Primary Cilia |
| title_short | Aurora A and AKT Kinase Signaling Associated with Primary Cilia |
| title_sort | aurora a and akt kinase signaling associated with primary cilia |
| topic | primary cilium aurora kinase A AKT kinase trichoplein lipid raft proliferation |
| url | https://www.mdpi.com/2073-4409/10/12/3602 |
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