Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study
Background: Chronic Hepatitis C (CHC) infection is the most common chronic liver disease in patients with end-stage renal disease (ESRD) and highly prevalent on hemodialysis patients. The DOPPS data reported an overall prevalence of 13.5 percent among adult hemodialysis patients. The reported data...
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| Format: | Article |
| Language: | English |
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Advance Educational Institute & Research Centre
2017-12-01
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| Series: | International Journal of Endorsing Health Science Research |
| Subjects: | |
| Online Access: | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/170/243 |
| _version_ | 1818887963739684864 |
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| author | Rahmat Ali Khan Anwar Ali Ali Yasir Khan |
| author_facet | Rahmat Ali Khan Anwar Ali Ali Yasir Khan |
| author_sort | Rahmat Ali Khan |
| collection | DOAJ |
| description | Background: Chronic Hepatitis C (CHC) infection is the most common chronic liver disease in patients with end-stage renal disease (ESRD) and highly prevalent on hemodialysis patients. The DOPPS data reported an overall prevalence of 13.5 percent among adult hemodialysis patients. The reported data in Pakistan reflected 26.02% hemodialysis patients with HCV infection. Over the last few years, the direct-acting antivirals have been revolutionary in the treatment of hepatitis C, and sofosbuvir (SOF) is the backbone of most modern treatment strategies with better prognosis of the infection and tolerability. The aim of the study was to assess the effectiveness and safety of Sofosbuvir regime on HCV infected patients on hemodialysis (HD) in the local population as per routine practice.
Method: This was an observational, prospective; single-center study enrolled 30 HCV HD subjects on sofosbuvir ribavirin regime for 12 weeks.
Results: As per results of 30 subjects’ (n= female 13, 44% and n = male 17, 56 %) with mean age ± standard deviation 60.5 ± 7.5 years. On SOF/ribavirin (RBV) treatment for 12 weeks, the sustained virological response rate was 100% (27 of 27) at 12 weeks. 95% confidence interval, (95 to 100). No patients had virologic failure during treatment. No patient had treatment discontinuation due to side effects. Adverse events were reported in at least 10% of the patients were mainly pruritus, fatigue, and nausea. No serious adverse event reported.
Conclusions: The Sofosbuvir based antiviral therapy is safe and effective in the treatment of HCV with ESRD, including HD patients with a high rate of SVR in patients. |
| first_indexed | 2024-12-19T16:45:35Z |
| format | Article |
| id | doaj.art-f074bc7c3c054345ba4bdacd4c49e323 |
| institution | Directory Open Access Journal |
| issn | 2307-3748 2310-3841 |
| language | English |
| last_indexed | 2024-12-19T16:45:35Z |
| publishDate | 2017-12-01 |
| publisher | Advance Educational Institute & Research Centre |
| record_format | Article |
| series | International Journal of Endorsing Health Science Research |
| spelling | doaj.art-f074bc7c3c054345ba4bdacd4c49e3232022-12-21T20:13:40ZengAdvance Educational Institute & Research CentreInternational Journal of Endorsing Health Science Research2307-37482310-38412017-12-01542832https://doi.org/10.29052/IJEHSR.v5.i4.2017.28-32Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre StudyRahmat Ali Khan0Anwar Ali1Ali Yasir Khan2Nawaz Sharif Kidney Hospital, Swat, Pakistan.Kings International Hospital, Swat, Pakistan.Clinical Research & Pharmacovigilance, TSCL (Searle), PakistanBackground: Chronic Hepatitis C (CHC) infection is the most common chronic liver disease in patients with end-stage renal disease (ESRD) and highly prevalent on hemodialysis patients. The DOPPS data reported an overall prevalence of 13.5 percent among adult hemodialysis patients. The reported data in Pakistan reflected 26.02% hemodialysis patients with HCV infection. Over the last few years, the direct-acting antivirals have been revolutionary in the treatment of hepatitis C, and sofosbuvir (SOF) is the backbone of most modern treatment strategies with better prognosis of the infection and tolerability. The aim of the study was to assess the effectiveness and safety of Sofosbuvir regime on HCV infected patients on hemodialysis (HD) in the local population as per routine practice. Method: This was an observational, prospective; single-center study enrolled 30 HCV HD subjects on sofosbuvir ribavirin regime for 12 weeks. Results: As per results of 30 subjects’ (n= female 13, 44% and n = male 17, 56 %) with mean age ± standard deviation 60.5 ± 7.5 years. On SOF/ribavirin (RBV) treatment for 12 weeks, the sustained virological response rate was 100% (27 of 27) at 12 weeks. 95% confidence interval, (95 to 100). No patients had virologic failure during treatment. No patient had treatment discontinuation due to side effects. Adverse events were reported in at least 10% of the patients were mainly pruritus, fatigue, and nausea. No serious adverse event reported. Conclusions: The Sofosbuvir based antiviral therapy is safe and effective in the treatment of HCV with ESRD, including HD patients with a high rate of SVR in patients.http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/170/243hepatitis chemodialysis patientssofosbuvirpakistani population |
| spellingShingle | Rahmat Ali Khan Anwar Ali Ali Yasir Khan Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study International Journal of Endorsing Health Science Research hepatitis c hemodialysis patients sofosbuvir pakistani population |
| title | Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study |
| title_full | Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study |
| title_fullStr | Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study |
| title_full_unstemmed | Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study |
| title_short | Effectiveness of Sofosbuvir regime in Hepatitis C virus infection in hemodialysis Pakistani patients: Single Centre Study |
| title_sort | effectiveness of sofosbuvir regime in hepatitis c virus infection in hemodialysis pakistani patients single centre study |
| topic | hepatitis c hemodialysis patients sofosbuvir pakistani population |
| url | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/170/243 |
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