Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

This study examined the metabolism of flavonolignans and taxifolin in 33 healthy adult male volunteers, who received 200 mg of silymarin orally twice daily for three months. First-morning urine and feces collected on days 10 and 90 were analyzed by UHPLC-MS and bacterial composition of feces was inv...

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Bibliographic Details
Main Authors: Kateřina Lněničková, Jiří Vrba, Pavel Kosina, Barbora Papoušková, Chahrazed Mekadim, Jakub Mrázek, Milan Sova, Eliška Sovová, Kateřina Valentová, Vladimír Křen, Pavla Kouřilová, Jana Vrbková, Jitka Ulrichová
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Functional Foods
Subjects:
Flavonolignans
Silybin
Taxifolin
Human metabolites
Mass spectrometry
Fecal microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622004613

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